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（Iso）-Flavokawain A

Name: （Iso）-Flavokawain A
Brand: TargetMol
SKU: T3S0737
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S0737Cas No. 3420-72-2

Alias Flavokavain A

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

（Iso）-Flavokawain A

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Purity: 99.72%

Catalog No. T3S0737Alias Flavokavain ACas No. 3420-72-2

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$66	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.72%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Synonyms

Flavokavain A

Chemical Properties

Molecular Weight	314.332
Formula	C₁₈H₁₈O₅
Cas No.	3420-72-2
Smiles	O=C(C=CC1=CC=C(OC)C=C1)C=2C(O)=CC(OC)=CC2OC
Relative Density.	1.207g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (174.97 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1813 mL	15.9067 mL	31.8135 mL	159.0675 mL
5 mM	0.6363 mL	3.1813 mL	6.3627 mL	31.8135 mL
10 mM	0.3181 mL	1.5907 mL	3.1813 mL	15.9067 mL
20 mM	0.1591 mL	0.7953 mL	1.5907 mL	7.9534 mL
50 mM	0.0636 mL	0.3181 mL	0.6363 mL	3.1813 mL
100 mM	0.0318 mL	0.1591 mL	0.3181 mL	1.5907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc