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ML-097 (CID-2160985) is a universal activator of Ras-related GTPases.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $59 | In Stock | In Stock | |
| 10 mg | $87 | In Stock | In Stock | |
| 25 mg | $143 | In Stock | In Stock | |
| 50 mg | $213 | In Stock | In Stock | |
| 100 mg | $318 | In Stock | In Stock | |
| 500 mg | $763 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $65 | In Stock | In Stock |
| Description | ML-097 (CID-2160985) is a universal activator of Ras-related GTPases. |
| In vitro | Activators of Cdc42 function might have a beneficial function in solid tumors and ameliorate faciogenital dysplasia where Cdc42 GEF is mutant. Rho GTPases affect cell proliferation and migration (11). In some cases underexpression is associated with cancer[1]. |
| In vivo | Rac2 is selectively expressed in immune cells and human Rac2 mutations result in immunodeficiency. Therefore, activators of Rac2 or other Rac family members might be of benefit in these diseases. Rac1 is important for maintaining hair follicle integrity and a rac1 deficiency in the skin causes nearly complete hair loss in an animal model[1]. |
| Molecular Weight | 307.139 |
| Formula | C14H11BrO3 |
| Cas No. | 743456-83-9 |
| Smiles | OC(=O)c1ccccc1OCc1ccccc1Br |
| Relative Density. | 1.514 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (13.02 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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