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Nisin Z
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Catalog No. T76264Cas No. 137061-46-2
Nisin Z has anti-inflammatory activity and reduces pro-inflammatory cytokine release by inhibiting activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways, attenuating lipopolysaccharide-induced mastitis through inhibition of the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways.
Nisin Z
😃Good
Catalog No. T76264Cas No. 137061-46-2
Nisin Z has anti-inflammatory activity and reduces pro-inflammatory cytokine release by inhibiting activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways, attenuating lipopolysaccharide-induced mastitis through inhibition of the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 g | $40 | In Stock | In Stock | |
| 10 g | $56 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Potency:1000 IU/mg
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nisin Z has anti-inflammatory activity and reduces pro-inflammatory cytokine release by inhibiting activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways, attenuating lipopolysaccharide-induced mastitis through inhibition of the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways. |
| In vitro | Nisin Z (10 μg/mL, 24 h) promoted the detachment and differentiation of gingival fibroblasts.Nisin Z (25-75 μg/mL, 24 h) inhibited the adhesion of C. albicans to gingival cells. [2] Nisin Z (500 and 1000 μg/mL, 24 hours) inhibited the formation of germ tubes in C. albicans. [3] Nisin Z (100 μg/mL, 12 h) decreased LPS-induced secretion of pro-inflammatory cytokines (e.g., IL-6, TNF-α, IL-1β) in MCF10A cells Nisin Z (10-100 μg/mL, 12 h) inhibited LPS-induced activation of the ERK1/2 and p38 MAPK signaling pathways in MCF10A cells. [4] |
| In vivo | Nisin Z (1, 5 and 10 mg/kg, intraperitoneal injection) helps to prevent pathological damage in LPS-induced mouse mastitis model. [4] |
| Molecular Weight | 3331.03 |
| Formula | C141H229N41O38S7 |
| Cas No. | 137061-46-2 |
| Smiles | O=C(NC(C(=O)O)CCCCN)C(=C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1NC(=O)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C3NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C4NC(=O)CNC(=O)C5N(C(=O)C(NC(=O)C6NC(=O)C(NC(=O)C(=C)NC(=O)C(NC(=O)C(NC(=O)C(=CC)NC(=O)C(N)C(C)CC)CSC6)C(C)CC)CC(C)C)C(SC4)C)CCC5)CCCCN)C(SC3)C)C)CC(C)C)CCSC)CC(=O)N)CCSC)CCCCN)C(SC2)C)C)C(SC1)C)CC(=O)N)CO)C(C)CC)CC7=CN=CN7)C(C)C |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 8 mg/mL (2.4 mM), Sonication is recommended. DMSO: 1 mg/mL (0.3 mM), Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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