Shopping Cart

Your shopping cart is currently empty

trans-Trimethoxyresveratrol

Name: trans-Trimethoxyresveratrol
Brand: TargetMol
SKU: T3330
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T3330Cas No. 22255-22-7

Alias Tri-O-methylresveratrol, Trimethoxystilbene, trans-trismethoxy Resveratrol, MR-3, E-Resveratrol Trimethyl Ether, 3,4',5-Trimethoxy-trans-stilbene

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

trans-Trimethoxyresveratrol

Copy Product Info

😃Good

Purity: 99.98%

Catalog No. T3330Alias Tri-O-methylresveratrol, Trimethoxystilbene, trans-trismethoxy Resveratrol, MR-3, E-Resveratrol Trimethyl Ether, 3,4',5-Trimethoxy-trans-stilbeneCas No. 22255-22-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$73	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

trans-Trimethoxyresveratrol AI Summary

trans-Trimethoxyresveratrol exhibits significant cytotoxic and antiproliferative activities against a broad range of cancer cell lines, including non-small cell lung cancer (A-549), breast cancer (MCF-7 and T47D), colon cancer (HT-29), melanoma (SKMEL-5), pancreatic adenocarcinoma (BxPC3), central nervous system cell lines (SF268), prostate carcinoma (DU145), and more. The compound shows inhibitory effects on cell proliferation, with varying concentrations required for half-maximal inhibition. trans-Trimethoxyresveratrol inhibits tubulin polymerization, a mechanism suggesting its potential as an anti-cancer agent. It also demonstrates potent inhibition of several cytochrome P450 enzymes, particularly CYP1B1, with variable IC50 values, thus indicating enzyme-specific selectivity. Furthermore, it acts as an antagonist for the aryl hydrocarbon receptor (AhR) and as an agonist for the estrogen receptor (ER) alpha. The compound has exhibited significant anti-inflammatory and antioxidant properties, including the inhibition of nitric oxide production and reactive oxygen species (ROS). Antimicrobial activity has also been observed against Staphylococcus aureus. In vivo, trans-Trimethoxyresveratrol has shown antitumor efficacy in mouse models, reducing tumor weight and volume in HT-29 xenografts. The compound's ability to induce apoptosis in leukemia cell lines (e.g., HL60) adds to its potential utility in cancer therapy. Overall, trans-Trimethoxyresveratrol's multifaceted bioactivity, including anticancer, enzyme inhibition, anti-inflammatory, antimicrobial, and antioxidant properties, highlights its potential as a therapeutic agent warranting further investigational studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.
Synonyms	Tri-O-methylresveratrol, Trimethoxystilbene, trans-trismethoxy Resveratrol, MR-3, E-Resveratrol Trimethyl Ether, 3,4',5-Trimethoxy-trans-stilbene

Chemical Properties

Molecular Weight	270.32
Formula	C₁₇H₁₈O₃
Cas No.	22255-22-7
Smiles	C(=C/C1=CC=C(OC)C=C1)\C2=CC(OC)=CC(OC)=C2
Relative Density.	1.104g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (184.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6993 mL	18.4966 mL	36.9932 mL	184.9660 mL
5 mM	0.7399 mL	3.6993 mL	7.3986 mL	36.9932 mL
10 mM	0.3699 mL	1.8497 mL	3.6993 mL	18.4966 mL
20 mM	0.1850 mL	0.9248 mL	1.8497 mL	9.2483 mL
50 mM	0.0740 mL	0.3699 mL	0.7399 mL	3.6993 mL
100 mM	0.0370 mL	0.1850 mL	0.3699 mL	1.8497 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc