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Anti-TGM2 Antibody (9Q248)
😃Good
Catalog No. TMAH-01166
Alias transglutaminase 2, TGC, TG2, HEL-S-45, G-α-h, GNAH, G-ALPHA-h
Anti-TGM2 Antibody (9Q248) is a Mouse antibody targeting TGM2. Anti-TGM2 Antibody (9Q248) can be used in ELISA, WB, IHC.
Anti-TGM2 Antibody (9Q248)
Anti-TGM2 Antibody (9Q248)
😃Good
Catalog No. TMAH-01166Alias transglutaminase 2, TGC, TG2, HEL-S-45, G-α-h, GNAH, G-ALPHA-h
Anti-TGM2 Antibody (9Q248) is a Mouse antibody targeting TGM2. Anti-TGM2 Antibody (9Q248) can be used in ELISA, WB, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μg | $208 | 7-10 days | |
| 100 μg | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, WB, IHC Reactivity: Human |
| Alias | transglutaminase 2, TGC, TG2, HEL-S-45, G-α-h, GNAH, G-ALPHA-h |
| Ig Type | IgG |
| Clone | 9Q248 |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical of paraffin-embedded Human placenta tissue using TMAH-01166 at dilution of 1:200. 2. Immunohistochemical of paraffin-embedded Human Breast tissue using TMAH-01166 at dilution of 1:200. 3. Western Blot -All lanes: Mouse anti-TGM2 Monoclonal antibody at 1μg/ml -Lane 1 : A549 whole cell lysate -Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution -Predicted band size :77kd -Observed band size :77,62,39KD -Additional bands at :30kd |
| Application | ELISA, WB, IHC |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm, cytosol. Nucleus. Chromosome. Secreted, extracellular space, extracellular matrix. Cell membrane. Mitochondrion.; [Isoform 2]: Cytoplasm, perinuclear region. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components. In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively. Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases. Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3. Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription. Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system. Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2. Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate. Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet. May also act as an isopeptidase cleaving the previously formed cross-links. Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism. Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) |
| Antigen Species | Human |
| Gene ID | 7052 |
| Uniprot ID | |
| Biology Area | Cell Biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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