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Anti-KRT14 Antibody (3N758)
😃Good
Catalog No. TMAY-00068
Alias NFJ, K14, EBS4, EBS3, EBS1D, EBS1C, EBS1B, EBS1A, EBS1, CK14
Anti-KRT14 Antibody (3N758) is a Mouse antibody targeting KRT14. Anti-KRT14 Antibody (3N758) can be used in IHC-P.
Anti-KRT14 Antibody (3N758)
Anti-KRT14 Antibody (3N758)
😃Good
Catalog No. TMAY-00068Alias NFJ, K14, EBS4, EBS3, EBS1D, EBS1C, EBS1B, EBS1A, EBS1, CK14
Anti-KRT14 Antibody (3N758) is a Mouse antibody targeting KRT14. Anti-KRT14 Antibody (3N758) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | NFJ, K14, EBS4, EBS3, EBS1D, EBS1C, EBS1B, EBS1A, EBS1, CK14 |
| Ig Type | Mouse IgG2a |
| Clone | 3N758 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human KRT14 in human skin with mouse monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human KRT14 in human esophageal carcinoma with mouse monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:10000-1:20000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cytokeratin 14, also known as Keratin 14 and K14, is a member of the keratin family. Cytokeratin 14 is a type I keratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Cytokeratin 14 is mainly expressed in the basal layer. It is also strongly expressed in the outer root sheath of anagen follicles. Cytokeratin 14 and keratin 5 may have a role in the maintenance of cell proliferation potential in the basal layer of stratified epithelia, modulating phosphatidylinositol 3-kinase/Akt–mediated cell proliferation and/or Notch1-dependent cell differentiation. Cytokeratin 14 defect prevents it from working effectively with keratin 5 and interfering with the assembly of the keratin intermediate filament network. A disruption in this network makes keratinocytes fragile and prone to rupture. Minor trauma to the skin, such as rubbing or scratching, can cause these cells to break down, resulting in the formation of painful, fluid-filled blisters. Mutations in the K14 gene are also responsible for Naegeli-Franceschetti-Jadassohn syndrome and Dermatopathia Pigmentosa Reticularis. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: C-terminus of the Human Cytokeratin 14/KRT14 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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