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Anti-FKBP38 Polyclonal Antibody
😃Good
Catalog No. TMAB-06046
Anti-FKBP38 Polyclonal Antibody is a Rabbit antibody targeting FKBP38. Anti-FKBP38 Polyclonal Antibody can be used in WB.
Anti-FKBP38 Polyclonal Antibody
Anti-FKBP38 Polyclonal Antibody
😃Good
Catalog No. TMAB-06046
Anti-FKBP38 Polyclonal Antibody is a Rabbit antibody targeting FKBP38. Anti-FKBP38 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-FKBP38 Polyclonal Antibody is a Rabbit antibody targeting FKBP38. Anti-FKBP38 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Chicken,Dog,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion membrane. |
| Tissue Specificity | Widely expressed. Highest levels seen in the brain. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | FKBP8 is an immunophilin family member lacking PPIase/arotamase activity that influences immunoregulation, protein folding and trafficking in neurons associated with memory function. The FKBPr38 form derives from a truncated ORF. Presenilin 1 and 2 form molecular complexes with anti-apoptotic Bcl-2, and promote degradation of FKBP38 and Bcl-2, and sequester these proteins in ER/Golgi, thereby inhibiting FKBPr38-mediated, γ-secretase-independent, mitochondrial targeting of Bcl-2. FKBP8 present in the central nervous system can antagonize hedgehog (HH) signaling, where HH is critical for patterning and growth of many tissues in the developing embryo. Mouse FKBPr38 mRNA is present in neurons and glial cells and appears more pronounced in neurons associated with the hippocampal formation in adult mouse brains. |
| Immunogen | KLH conjugated synthetic peptide: human FKBP38 |
| Antigen Species | Human |
| Gene Name | FKBP8 |
| Gene ID | |
| Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP8 |
| Uniprot ID | |
| Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. |
| Molecular Weight | Theoretical: 46 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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