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Pristinamycin (Synonyms: Pristinamycine)

Name: Pristinamycin
Brand: TargetMol
SKU: T75278
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T75278 Copy Product Info

Purity: 99.99%

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Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). These components act synergistically to inhibit bacterial protein synthesis. Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA), and Vancomycin-resistant Enterococcus faecium (VREF).

Pristinamycin

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Catalog No. T75278

Synonyms Pristinamycine

Cas No. 270076-60-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$328	-	In Stock
25 mg	$689	-	In Stock
50 mg	$1,090	-	In Stock
100 mg	$1,480	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). These components act synergistically to inhibit bacterial protein synthesis. Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA), and Vancomycin-resistant Enterococcus faecium (VREF).
In vitro	In vitro studies demonstrate that Pristinamycin possesses broad-spectrum antimicrobial potency. Research indicates that it effectively inhibits the growth of Staphylococcus and Streptococcus species, with a minimum inhibitory concentration (MIC) typically less than or equal to 0.78 mg/L. It remains highly effective against erythromycin-resistant strains [2].
In vivo	In vivo, Pristinamycin activity was evaluated in mice infected with Chlamydia psittaci. At a dose of 100 mg/kg, the antibiotic showed significant activity, effectively reducing mortality rates compared to the 70% mortality observed in the control group [3].
Synonyms	Pristinamycine

Chemical Properties

Molecular Weight	1392.55
Formula	C₇₃H₈₉N₁₁O₁₇
Cas No.	270076-60-3
Smiles	CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c2coc(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C)n2.[H][C@@]12CCCN1C(=O)[C@@H](CC)NC(=O)[C@@H](NC(=O)c1ncccc1O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@]1([H])CC(=O)CCN1C(=O)[C@H](Cc1ccc(cc1)N(C)C)N(C)C2=O)c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (57.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7181 mL	3.5905 mL	7.1811 mL	35.9054 mL
5 mM	0.1436 mL	0.7181 mL	1.4362 mL	7.1811 mL
10 mM	0.0718 mL	0.3591 mL	0.7181 mL	3.5905 mL
20 mM	0.0359 mL	0.1795 mL	0.3591 mL	1.7953 mL
50 mM	0.0144 mL	0.0718 mL	0.1436 mL	0.7181 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc