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Anti-Complement C5 beta chain Polyclonal Antibody
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Catalog No. TMAB-04546
Anti-Complement C5 beta chain Polyclonal Antibody is a Rabbit antibody targeting Complement C5 beta chain. Anti-Complement C5 beta chain Polyclonal Antibody can be used in FCM.
Anti-Complement C5 beta chain Polyclonal Antibody
Anti-Complement C5 beta chain Polyclonal Antibody
😃Good
Catalog No. TMAB-04546
Anti-Complement C5 beta chain Polyclonal Antibody is a Rabbit antibody targeting Complement C5 beta chain. Anti-Complement C5 beta chain Polyclonal Antibody can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Complement C5 beta chain Polyclonal Antibody is a Rabbit antibody targeting Complement C5 beta chain. Anti-Complement C5 beta chain Polyclonal Antibody can be used in FCM. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 2μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Activation of the complement system plays a key role in normal inflammatory response to injury but may cause substantial injury when activated inappropriately. The complement system is activated either through the classical (antibody induced) or the alternative (microbial surface, polysacharride induced) pathway, both leading to the formation of the C5b9 complex. Fluid phase binding of the multifunctional glycoprotein S protein (vitronectin) to C5b9 leads to the formation of a cytolytically inactive complex, SC5b9, which is unable to attach to cells. |
| Immunogen | KLH conjugated synthetic peptide: human Complement C5 beta chain |
| Antigen Species | Human |
| Gene Name | C5 |
| Gene ID | |
| Protein Name | Complement C5 |
| Uniprot ID | |
| Function | Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). |
| Molecular Weight | Theoretical: 72 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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