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Tetrandrine
🥰Excellent
Catalog No. T2996Cas No. 518-34-3
Alias Sinomenine A, NSC-77037, Hanfangchin A, Fanchinine, d-Tetrandrine
Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.
Tetrandrine
🥰Excellent
Purity: 99.72%
Catalog No. T2996Alias Sinomenine A, NSC-77037, Hanfangchin A, Fanchinine, d-TetrandrineCas No. 518-34-3
Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $43 | In Stock | |
| 500 mg | $89 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock |
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CitedSelect Batch
Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels. |
| In vitro | METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tetrandrine (1-3 µM) for 24-72 h, and cell numbers were measured. RESULTS: 2 µM and 3 µM Tetrandrine significantly inhibited cell proliferation. [1] METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tetrandrine (5 µM) for 16 h and GFP-LC3 spots were detected. RESULTS: Tetrandrine significantly induced GFP-LC3 spot formation with similar potency (5 µM) in all cell lines tested.Tetrandrine induced autophagy in multiple cell lines. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, athymic nude mice bearing THP-1 xenografts were administered Tetrandrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days. RESULTS: Tetrandrine treatment reduced tumor growth. [1] |
| Alias | Sinomenine A, NSC-77037, Hanfangchin A, Fanchinine, d-Tetrandrine |
| Molecular Weight | 622.75 |
| Formula | C38H42N2O6 |
| Cas No. | 518-34-3 |
| Smiles | O(C)C1=C2C=3[C@](CC=4C=C(C(OC)=CC4)OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)(N(C)CCC3C=C1OC)[H] |
| Relative Density. | 1.17 g/cm3 (20°C) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 12.45 mg/mL (19.99 mM), Sonication and heating are recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 0.7 mg/mL (1.12 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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