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NS-638

Name: NS-638
Brand: TargetMol
SKU: T3543
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3543Cas No. 150493-34-8

Alias NS 638

NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).

NS-638

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Purity: 98.44%

Catalog No. T3543Alias NS 638Cas No. 150493-34-8

NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$385	In Stock	In Stock
100 mg	$522	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.44%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
Targets&IC50	Ca2+ channel:3.4 μM
In vitro	NS-638 dose-dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons (IC50: 2.3 and 4.3 μM), respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked (IC50: 3.4 μM). At this concentration, no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells (1-30 μM).
In vivo	In the mouse model of middle cerebral artery occlusion, NS-638 administration (50 mg/kg, i.p.) at 1 hour and 6 hours after ischemia, followed by daily dosing for two subsequent days, leads to a 48% decrease in overall infarct volume. However, it fails to demonstrate neuroprotective effects in the gerbil model of bilateral carotid artery occlusion against ischemic neuronal damage.
Cell Research	NS-638 is prepared in 1% DMSO and 1% ethanol. The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].
Synonyms	NS 638

Chemical Properties

Molecular Weight	325.72
Formula	C₁₅H₁₁ClF₃N₃
Cas No.	150493-34-8
Smiles	Nc1nc2cc(ccc2n1Cc1ccc(Cl)cc1)C(F)(F)F
Relative Density.	1.45g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (168.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0701 mL	15.3506 mL	30.7012 mL	153.5061 mL
5 mM	0.6140 mL	3.0701 mL	6.1402 mL	30.7012 mL
10 mM	0.3070 mL	1.5351 mL	3.0701 mL	15.3506 mL
20 mM	0.1535 mL	0.7675 mL	1.5351 mL	7.6753 mL
50 mM	0.0614 mL	0.3070 mL	0.6140 mL	3.0701 mL
100 mM	0.0307 mL	0.1535 mL	0.3070 mL	1.5351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc