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20-(tert-Butoxy)-20-oxoicosanoic acid

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Catalog No. T9785Cas No. 683239-16-9

20-(tert-Butoxy)-20-oxoicosanoic acid is an alkyl-chain-based, non-cleavable PROTAC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

20-(tert-Butoxy)-20-oxoicosanoic acid

20-(tert-Butoxy)-20-oxoicosanoic acid

🥰Excellent
Catalog No. T9785Cas No. 683239-16-9
20-(tert-Butoxy)-20-oxoicosanoic acid is an alkyl-chain-based, non-cleavable PROTAC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
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500 mg$29In Stock
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Purity:≥98%
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Product Introduction

Bioactivity
Description
20-(tert-Butoxy)-20-oxoicosanoic acid is an alkyl-chain-based, non-cleavable PROTAC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
In vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
Chemical Properties
Molecular Weight398.62
FormulaC24H46O4
Cas No.683239-16-9
SmilesO(C(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(C)(C)C
Relative Density.0.942 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PROTACLinkerPROTAC LinkersPROTAC LinkerNon-cleavableInhibitorinhibitAntibody-drug conjugates linkersAlkyl-ChainADCLinkerADC LinkersADC Linker20-(tert-Butoxy)-20-oxoicosanoic acid20(tertButoxy)20oxoicosanoic acid20 (tert Butoxy) 20 oxoicosanoic acid
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