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Anti-Bcl-2 Antibody (7L839)
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Catalog No. TMAB-03054
Anti-Bcl-2 Antibody (7L839) is a Mouse antibody targeting Bcl-2. Anti-Bcl-2 Antibody (7L839) can be used in WB,ICC/IF,FCM.
Anti-Bcl-2 Antibody (7L839)
Anti-Bcl-2 Antibody (7L839)
😃Good
Catalog No. TMAB-03054
Anti-Bcl-2 Antibody (7L839) is a Mouse antibody targeting Bcl-2. Anti-Bcl-2 Antibody (7L839) can be used in WB,ICC/IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 μg | $1,058 | 7-10 days | 7-10 days | |
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Bcl-2 Antibody (7L839) is a Mouse antibody targeting Bcl-2. Anti-Bcl-2 Antibody (7L839) can be used in WB,ICC/IF,FCM. |
| Ig Type | IgG1 |
| Clone | 7L839 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:1000-5000; ICC/IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in a variety of tissues. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1mg/ml |
| Research Background | The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8). |
| Immunogen | Recombinant Protein: human Bcl-2 protein |
| Antigen Species | Human |
| Gene Name | BCL2 |
| Gene ID | |
| Protein Name | Apoptosis regulator Bcl-2 |
| Uniprot ID | |
| Function | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). |
| Molecular Weight | Theoretical: 26 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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