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A2764 dihydrochloride

Name: A2764 dihydrochloride
Brand: TargetMol
SKU: T7775
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7775Cas No. 861038-72-4

A2764 dihydrochloride is a highly selective inhibitor of TWIK-related spinal cord K+ channel (TRESK).

A2764 dihydrochloride

🥰Excellent

Purity: 99.05%

Catalog No. T7775Cas No. 861038-72-4

A2764 dihydrochloride is a highly selective inhibitor of TWIK-related spinal cord K+ channel (TRESK).

Pack Size	Price	Availability
5 mg	$35	In Stock
10 mg	$58	In Stock
25 mg	$103	In Stock
50 mg	$173	In Stock
100 mg	$269	In Stock
200 mg	$385	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Batch Information

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Purity:99.05%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	A2764 dihydrochloride is a highly selective inhibitor of TWIK-related spinal cord K+ channel (TRESK).
Targets&IC50	TRESK activated channel (mouse):(6.8 μM)

Chemical Properties

Molecular Weight	351.7
Formula	C₁₅H₂₁Cl₃N₂O
Cas No.	861038-72-4
Smiles	Cl.Cl.CCN(CC)CCOc1ccc(Cl)c2cccnc12
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.67 mg/mL (118.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8433 mL	14.2167 mL	28.4333 mL	142.1666 mL
5 mM	0.5687 mL	2.8433 mL	5.6867 mL	28.4333 mL
10 mM	0.2843 mL	1.4217 mL	2.8433 mL	14.2167 mL
20 mM	0.1422 mL	0.7108 mL	1.4217 mL	7.1083 mL
50 mM	0.0569 mL	0.2843 mL	0.5687 mL	2.8433 mL
100 mM	0.0284 mL	0.1422 mL	0.2843 mL	1.4217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc