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Anti-FGFR3 Antibody (5Y560) is a Rabbit antibody targeting FGFR3. Anti-FGFR3 Antibody (5Y560) can be used in ELISA,ELISA(Det).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $92 | 7-10 days | |
100 μL | $270 | 7-10 days |
Description | Anti-FGFR3 Antibody (5Y560) is a Rabbit antibody targeting FGFR3. Anti-FGFR3 Antibody (5Y560) can be used in ELISA,ELISA(Det). |
Alias | JTK4, HSFGFR3EX, fibroblast growth factor receptor 3, CEK2, CD333, ACH |
Ig Type | Monoclonal Rabbit IgG |
Clone | 5Y560 |
Reactivity | Mouse |
Application | ELISA,ELISA(Det) |
Recommended Dose | ELISA: 1:5000-1:10000; ELISA(Det): 1:1000-1:10000 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FGFR3 / CD333 (rM FGFR3 / CD333; TMPY-01208; NP_032036.2; Met1-Tyr367). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | Unconjugated |
Immunogen | Recombinant Mouse FGFR3 / CD333 protein (TMPY-01208) |
Antigen Species | Mouse |
Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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