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Anti-FGFR3 Antibody (5Y560)
😃Good
Catalog No. TMAY-03076
Alias JTK4, HSFGFR3EX, fibroblast growth factor receptor 3, CEK2, CD333, ACH
Anti-FGFR3 Antibody (5Y560) is a Rabbit antibody targeting FGFR3. Anti-FGFR3 Antibody (5Y560) can be used in ELISA,ELISA(Det).
Anti-FGFR3 Antibody (5Y560)
Anti-FGFR3 Antibody (5Y560)
😃Good
Catalog No. TMAY-03076Alias JTK4, HSFGFR3EX, fibroblast growth factor receptor 3, CEK2, CD333, ACH
Anti-FGFR3 Antibody (5Y560) is a Rabbit antibody targeting FGFR3. Anti-FGFR3 Antibody (5Y560) can be used in ELISA,ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $92 | 7-10 days | |
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, ELISA(Det) Reactivity: Mouse |
| Alias | JTK4, HSFGFR3EX, fibroblast growth factor receptor 3, CEK2, CD333, ACH |
| Ig Type | Rabbit IgG |
| Clone | 5Y560 |
| Reactivity | Mouse |
| Application | ELISA,ELISA(Det) |
| Recommended Dose | ELISA: 1:5000-1:10000; ELISA(Det): 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FGFR3 / CD333 (rM FGFR3 / CD333; TMPY-01208; NP_032036.2; Met1-Tyr367). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse FGFR3 / CD333 protein (TMPY-01208) |
| Antigen Species | Mouse |
| Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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