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MSX-122
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Catalog No. T3992Cas No. 897657-95-3
Alias MSX122, MSX 122
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
MSX-122
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Purity: 99.15%
Catalog No. T3992Alias MSX122, MSX 122Cas No. 897657-95-3
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $35 | In Stock | In Stock | |
| 10 mg | $59 | In Stock | In Stock | |
| 25 mg | $119 | In Stock | In Stock | |
| 50 mg | $197 | In Stock | In Stock | |
| 100 mg | $307 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.15%
Appearance:Solid
Color:White
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Product Introduction
MSX-122 AI Summary
MSX-122 demonstrates multifaceted bioactivity including competitive inhibition of SDF-1/CXCR4 mediated invasion with an IC50 of less than 10.0 nM. It shows notable antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, presenting an inhibition of -3.68% and 0.12% respectively. Moreover, the compound inhibits the SARS-CoV-2 3CL-Pro protease by 4.29% at 20 µM. It possesses antifungal (MIC > 20000.0 nM) and antibacterial (MIC > 20000.0 nM) activities against various pathogens, alongside a lack of haemolysis on human RBCs (HC10 > 20.0 µM) and low cytotoxicity against HEK293 cells (CC50 > 20000.0 nM). Additionally, it inhibits human HDAC6 enzymatic activity by 19.06% with a commercial peptide substrate and 0.03% with a custom peptide substrate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM). |
| Targets&IC50 | CXCL12:10 nM , CXCR4:10 nM |
| Synonyms | MSX122, MSX 122 |
| Molecular Weight | 292.34 |
| Formula | C16H16N6 |
| Cas No. | 897657-95-3 |
| Smiles | C(Nc1ncccn1)c1ccc(CNc2ncccn2)cc1 |
| Relative Density. | 1.313 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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