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Solabegron

Name: Solabegron
Brand: TargetMol
SKU: T12970
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12970Cas No. 252920-94-8

Alias GW 427353

Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist that promotes cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR (EC50: 22 nM). It is used to treat overactive bladder and irritable bowel syndrome.

Solabegron

🥰Excellent

Purity: 97.89%

Catalog No. T12970Alias GW 427353Cas No. 252920-94-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$167	In Stock	In Stock
10 mg	$273	In Stock	In Stock
25 mg	$497	In Stock	In Stock
50 mg	$672	In Stock	In Stock
100 mg	$893	In Stock	In Stock
200 mg	$1,180	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist that promotes cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR (EC50: 22 nM). It is used to treat overactive bladder and irritable bowel syndrome.
Targets&IC50	β3-adrenoceptor:(EC50)22 Nm
In vivo	Solabegron(3 mg/kg i.v.)evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs.
Synonyms	GW 427353

Chemical Properties

Molecular Weight	410.89
Formula	C₂₃H₂₃ClN₂O₃
Cas No.	252920-94-8
Smiles	O[C@@H](CNCCNc1cccc(c1)-c1cccc(c1)C(O)=O)c1cccc(Cl)c1
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (608.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4337 mL	12.1687 mL	24.3374 mL	121.6871 mL
5 mM	0.4867 mL	2.4337 mL	4.8675 mL	24.3374 mL
10 mM	0.2434 mL	1.2169 mL	2.4337 mL	12.1687 mL
20 mM	0.1217 mL	0.6084 mL	1.2169 mL	6.0844 mL
50 mM	0.0487 mL	0.2434 mL	0.4867 mL	2.4337 mL
100 mM	0.0243 mL	0.1217 mL	0.2434 mL	1.2169 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc