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Tolfenpyrad
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Catalog No. T4445Cas No. 129558-76-5
Tolfenpyrad is an effective insecticide[1], used against pests that are resistant to existing insecticides such as organophosphates and carbamates.[2]
Tolfenpyrad
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Purity: 97%
Catalog No. T4445Cas No. 129558-76-5
Tolfenpyrad is an effective insecticide[1], used against pests that are resistant to existing insecticides such as organophosphates and carbamates.[2]
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $35 | In Stock | In Stock | |
| 50 mg | $56 | In Stock | In Stock | |
| 100 mg | $89 | In Stock | In Stock | |
| 200 mg | $127 | In Stock | In Stock | |
| 500 mg | $198 | In Stock | In Stock | |
| 1 g | $297 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:97%
Appearance:Solid
Color:White
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Product Introduction
Tolfenpyrad AI Summary
Tolfenpyrad exhibits broad-spectrum bioactivity, including significant insecticidal, cytotoxic, antiparasitic, antifungal, antibacterial, and anthelmintic activities. It demonstrates potent larvicidal effects against Helicoverpa armigera, Plutella xylostella, Myzus persicae, and green rice leafhopper, achieving up to 100% mortality at varying concentrations. In Mus musculus, it shows acute toxicity with an LD50 > 100.0 mg.kg-1. The compound significantly inhibits Liver Stage Plasmodium berghei sporozoites and displays anti-trypanosomal activity against Trypanosoma cruzi, T. brucei brucei, and T. brucei rhodesiense, as well as anti-leishmanial activity against Leishmania infantum in macrophages. Moreover, it inhibits Naegleria gruberi growth by 93.3% in vitro and displays antifungal and antibacterial activities, albeit with higher MIC values (>10,000 nM). In human HEK293 and MCF-10A cells, the compound is cytotoxic at concentrations >10,000 nM and 33,700 nM, respectively. It also shows haemolytic activity against human red blood cells with an HC10 > 10.0 uM. In toxicity studies, it affects Swiss mice with a maximum tolerated dose of 1.0 mg kg-1 and shows selective toxicity in rat FAO cells with significant impact on cell proliferation and respiration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tolfenpyrad is an effective insecticide[1], used against pests that are resistant to existing insecticides such as organophosphates and carbamates.[2] |
| Molecular Weight | 383.87 |
| Formula | C21H22ClN3O2 |
| Cas No. | 129558-76-5 |
| Smiles | CCc1nn(C)c(C(=O)NCc2ccc(Oc3ccc(C)cc3)cc2)c1Cl |
| Relative Density. | 1.21g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble DMSO: 55 mg/mL (143.28 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2.5 mg/mL (6.51 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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