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H-Tyr-Ala-OH

Name: H-Tyr-Ala-OH
Brand: TargetMol
SKU: T40840
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40840Cas No. 730-08-5

Alias Tyrosylalanine, H-Tyr-Ala-OH

Tyrosylalanine (H-Tyr-Ala-OH), a dipeptide comprising L-tyrosine and L-alanine, is referenced in studies [1] [2].

H-Tyr-Ala-OH

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Purity: 99.74%

Catalog No. T40840Alias Tyrosylalanine, H-Tyr-Ala-OHCas No. 730-08-5

Tyrosylalanine (H-Tyr-Ala-OH), a dipeptide comprising L-tyrosine and L-alanine, is referenced in studies [1] [2].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$38	In Stock	In Stock
50 mg	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

H-Tyr-Ala-OH AI Summary

H-Tyr-Ala-OH demonstrates a broad spectrum of bioactivities targeting various biological entities and processes. It has an IC50 greater than 500,000.0 nM for inhibiting Plasmodium falciparum Pfmrk. The compound shows a binding affinity at PKA with a Ki value of 2300.0 nM and inhibits CaM-KKbeta with a Ki of 13000.0 nM. Additionally, it binds to MLCK and PKC with Ki values of 150000.0 nM and 40000.0 nM, respectively, and inhibits PKG with a Ki of 1300.0 nM. It also interact with multiple kinases, altering the thermal stability of numerous proteins involved in cellular signaling. In microbial assays, H-Tyr-Ala-OH inhibits Escherichia coli D-alanine-D-alanine ligase B with an 85.3% inhibition rate at 2 mM concentration and inhibits Staphylococcus sp. APH(3')-3a with a Ki of 49000.0 nM. It is being evaluated for its effect on Polymerase Kappa with a potency of 21192.3 nM. Moreover, the compound shows a binding affinity to human CDK2 with a Kd of 286000.0 nM and exhibits antiviral activity against SARS-CoV-2 with IC50 values greater than 20000.0 nM. Lastly, H-Tyr-Ala-OH inhibits human HDAC6 activity as evidenced by inhibition percentages of -0.06% and -6.2% in enzymatic assays with commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tyrosylalanine (H-Tyr-Ala-OH), a dipeptide comprising L-tyrosine and L-alanine, is referenced in studies [1] [2].
Synonyms	Tyrosylalanine, H-Tyr-Ala-OH

Chemical Properties

Molecular Weight	252.27
Formula	C₁₂H₁₆N₂O₄
Cas No.	730-08-5
Smiles	C([C@@H](C(N[C@H](C(O)=O)C)=O)N)C1=CC=C(O)C=C1
Sequence	Tyr-Ala
Sequence Short	YA

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 120 mg/mL (475.68 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.9640 mL	19.8200 mL	39.6401 mL	198.2003 mL
5 mM	0.7928 mL	3.9640 mL	7.9280 mL	39.6401 mL
10 mM	0.3964 mL	1.9820 mL	3.9640 mL	19.8200 mL
20 mM	0.1982 mL	0.9910 mL	1.9820 mL	9.9100 mL
50 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9640 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9820 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc