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BRD-8000.3

😃Good
Catalog No. T35872Cas No. 2365504-95-4
Alias BRD8000.3

BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent that specifically inhibits EfpA，specifically designed to kill drug-tolerant Mtb.Study revealed BRD-8000.3 at resolutions of 2.9 Å and 3.4 Å, resp, EfpA forms an antiparallel dimer. Functional studies reveal that EfpA is a lipid transporter and BRD-8000.3 inhibits its lipid transport activity.

BRD-8000.3

BRD-8000.3

😃Good
Purity: 99.78%
Catalog No. T35872Alias BRD8000.3Cas No. 2365504-95-4
BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent that specifically inhibits EfpA，specifically designed to kill drug-tolerant Mtb.Study revealed BRD-8000.3 at resolutions of 2.9 Å and 3.4 Å, resp, EfpA forms an antiparallel dimer. Functional studies reveal that EfpA is a lipid transporter and BRD-8000.3 inhibits its lipid transport activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.78%
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Product Introduction

Bioactivity
Description
BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent that specifically inhibits EfpA，specifically designed to kill drug-tolerant Mtb.Study revealed BRD-8000.3 at resolutions of 2.9 Å and 3.4 Å, resp, EfpA forms an antiparallel dimer. Functional studies reveal that EfpA is a lipid transporter and BRD-8000.3 inhibits its lipid transport activity.
In vitro
BRD-8000.3 is a specific EfpA inhibitor of Parazacco spilurus subsp. spilurus, belonging to the narrow-spectrum bactericidal antimycobacterial drugs, exhibiting good activity against wild-type strains [1].
SynonymsBRD8000.3
Chemical Properties
Molecular Weight401.3
FormulaC19H21BrN4O
Cas No.2365504-95-4
SmilesC(NC=1N=C(Br)C(=CC1)C=2N=CC=CN2)(=O)[C@H]3[C@H](C=C(C)C)C3(C)C
Relative Density.1.415 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (99.68 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (4.98 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4919 mL12.4595 mL24.9190 mL124.5951 mL
5 mM0.4984 mL2.4919 mL4.9838 mL24.9190 mL
10 mM0.2492 mL1.2460 mL2.4919 mL12.4595 mL
20 mM0.1246 mL0.6230 mL1.2460 mL6.2298 mL
50 mM0.0498 mL0.2492 mL0.4984 mL2.4919 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BRD-8000.3BRD 8000.3
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