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Plazomicin sulfate
(Synonyms: ACHN 490 sulfate) Copy Product Info
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Synonyms: ACHN 490 sulfate
Catalog No. T206406 Copy Product Info
Purity: 97.07%
🥰Excellent
Plazomicin sulfate is a potent aminoglycoside antibiotic that combats antibiotic resistance. Plazomicin sulfate exhibits in vitro activity against multidrug-resistant bacteria including carbapenem-resistant Enterobacteriaceae. Plazomicin sulfate is utilized in antimicrobial susceptibility testing and infectious disease research models of multidrug-resistant complicated urinary tract infection (cUTI) and carbapenem-resistant Enterobacteriaceae infection systems.
Cas No. 1380078-95-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $100 | - | In Stock | |
| 5 mg | $247 | - | In Stock | |
| 10 mg | $396 | - | In Stock | |
| 25 mg | $648 | - | In Stock | |
| 50 mg | $912 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:97.07%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Plazomicin sulfate is a potent aminoglycoside antibiotic that combats antibiotic resistance. Plazomicin sulfate exhibits in vitro activity against multidrug-resistant bacteria including carbapenem-resistant Enterobacteriaceae. Plazomicin sulfate is utilized in antimicrobial susceptibility testing and infectious disease research models of multidrug-resistant complicated urinary tract infection (cUTI) and carbapenem-resistant Enterobacteriaceae infection systems. |
| In vitro | Methods:The minimum inhibitory concentrations of plazomicin sulfate against various Gram-negative bacteria were determined. Its inhibitory effects on transporters related to renal tubular secretion were evaluated, and its antibacterial activity against E. coli strains carrying aminoglycoside-modifying enzymes was verified. Results: 1.Against Klebsiella, Escherichia, Enterobacter, Serratia and Citrobacter, plazomicin sulfate showed an MIC₅₀ of 0.25–0.5 μg/mL and an MIC₉₀ of 0.5–1 μg/mL. 2.Plazomicin sulfate selectively inhibited MATE2-K and exerted weak effects on MATE1 and OCT2, all of which are key transporters for renal tubular secretion [1]. 3.After 18-hour treatment, plazomicin sulfate retained antibacterial activity against most E. coli BW25113 strains and E. coli BW25113 ΔbamB ΔtolC strains expressing aminoglycoside-modifying enzymes [2]. |
| Synonyms | ACHN 490 sulfate |
| Formula | C25H48N6O10.xH2SO4 |
| Cas No. | 1380078-95-4 |
| Smiles | O([C@H]1[C@H](NC([C@H](CCN)O)=O)C[C@H](N)[C@@H](O[C@H]2OC(CNCCO)=CC[C@H]2N)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3. xS(=O)(=O)(O)O |
| Storage | Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 80 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Plazomicin sulfate chemical structure | Plazomicin sulfate in vitro | Plazomicin sulfate formula
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