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Ledipasvir

Name: Ledipasvir
Brand: TargetMol
SKU: T6200
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6200Cas No. 1256388-51-8

Alias GS-5885

Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.

Ledipasvir

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Purity: 99.96%

Catalog No. T6200Alias GS-5885Cas No. 1256388-51-8

Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$90	In Stock	In Stock
25 mg	$162	In Stock	In Stock
50 mg	$270	In Stock	In Stock
100 mg	$468	In Stock	In Stock
500 mg	$1,070	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$90	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.96%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.
Targets&IC50	NS5A (1a replicon):34 pM(EC50), NS5A (1b replicon):4 pM(EC50)
In vitro	Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b. Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].
In vivo	Ledipasvir distinguishes itself not only for its substantial replicon potency but also for its low clearance, high bioavailability, and extended half-lives across several species (rat, dog, and monkey) alongside a low predicted clearance in humans. Its pharmacokinetics have been assessed in rats and dogs, demonstrating favorable plasma half-lives (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr), minimal systemic clearance (CL), and moderate distribution volumes (Vss) exceeding total body water volume[1].
Synonyms	GS-5885

Chemical Properties

Molecular Weight	889
Formula	C₄₉H₅₄F₂N₈O₆
Cas No.	1256388-51-8
Smiles	COC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1c1ncc([nH]1)-c1ccc2-c3ccc(cc3C(F)(F)c2c1)-c1ccc2nc([nH]c2c1)[C@@H]1[C@H]2CC[C@H](C2)N1C(=O)[C@@H](NC(=O)OC)C(C)C
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 255 mg/mL (286.84 mM), Sonication is recommended.

Ethanol: 93 mg/mL (104.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (5.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1249 mL	5.6243 mL	11.2486 mL	56.2430 mL
5 mM	0.2250 mL	1.1249 mL	2.2497 mL	11.2486 mL
10 mM	0.1125 mL	0.5624 mL	1.1249 mL	5.6243 mL
20 mM	0.0562 mL	0.2812 mL	0.5624 mL	2.8121 mL
50 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1249 mL
100 mM	0.0112 mL	0.0562 mL	0.1125 mL	0.5624 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc