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Diphenidol hydrochloride

Name: Diphenidol hydrochloride
Brand: TargetMol
SKU: T0862
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0862Cas No. 3254-89-5

Alias Diphenidol HCl, Difenidol hydrochloride

Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.

Diphenidol hydrochloride

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Purity: 99.33%

Catalog No. T0862Alias Diphenidol HCl, Difenidol hydrochlorideCas No. 3254-89-5

Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$34	In Stock	In Stock
100 mg	$47	In Stock	In Stock
500 mg	$89	In Stock	In Stock
1 g	$135	-	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.33%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Diphenidol hydrochloride AI Summary

Diphenidol hydrochloride demonstrates a multifaceted pharmacological profile with significant implications in both cardiovascular and antiviral therapies. In coronary artery ligated dog models, it exhibits dose-dependent antiarrhythmic effects at a dose of 5 mg/kg administered intravenously, reducing normal beats from 90.0% to 34.0% and lowering the heart rate from 200.0 to 142.0 beats per minute, with effects lasting over 2 hours. Additionally, Diphenidol hydrochloride displaces [3H]N-methylscopolamine from various human muscarinic receptors (M1-M5) with moderate to low affinity, indicated by its Ki values. It also displays inhibitory activity across a spectrum of targets, including Lamin A splicing, AmpC Beta-Lactamase, the ERK signaling pathway, Histone Lysine Methyltransferase G9a, and others, reflecting its broad bioactivity profile. In antiviral studies, Diphenidol hydrochloride shows activity against SARS-CoV-2, though the efficacy varies. It inhibits cell viability in Vero E6 cells with an inhibition index of 0.8904, yet demonstrates limited cytotoxicity inhibition in Vero-6 cells and a modest inhibition rate of 4.21% in Caco-2 cells at a 10 µM concentration. Furthermore, it reduces the SARS-CoV-2 3CL-Pro protease activity by 15.62% at 20 µM concentration. Collectively, these findings suggest that Diphenidol hydrochloride holds potential for diverse therapeutic applications, warranting further investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
Synonyms	Diphenidol HCl, Difenidol hydrochloride

Chemical Properties

Molecular Weight	345.91
Formula	C₂₁H₂₈ClNO
Cas No.	3254-89-5
Smiles	Cl.OC(CCCN1CCCCC1)(c1ccccc1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 34 mg/mL (98.29 mM), Sonication is recommended.

DMSO: 55 mg/mL (159 mM), Sonication is recommended.

H2O: 11 mg/mL (31.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8909 mL	14.4546 mL	28.9093 mL	144.5463 mL
5 mM	0.5782 mL	2.8909 mL	5.7819 mL	28.9093 mL
10 mM	0.2891 mL	1.4455 mL	2.8909 mL	14.4546 mL
20 mM	0.1445 mL	0.7227 mL	1.4455 mL	7.2273 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0578 mL	0.2891 mL	0.5782 mL	2.8909 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0289 mL	0.1445 mL	0.2891 mL	1.4455 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc