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Skimmianine

Name: Skimmianine
Brand: TargetMol
SKU: T2S2109
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S2109Cas No. 83-95-4

Alias Skimmianin, Skimmiamine, Chloroxylonine, beta-Fagarine

1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.

Skimmianine

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Purity: 97.85%

Catalog No. T2S2109Alias Skimmianin, Skimmiamine, Chloroxylonine, beta-FagarineCas No. 83-95-4

1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$159	In Stock	In Stock
10 mg	$255	In Stock	In Stock
25 mg	Preferential	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.85%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Skimmianine AI Summary

Skimmianine demonstrates a diverse range of bioactivities. It acts as an inhibitor of peak steady-state K+ currents in neuroblastoma cells N1E-115 (blocking by 20.0% at 50 µM) and Kv1.3 channels in mouse fibroblasts L929 (blocking by 13.0% at 50 µM), as well as peak steady-state Na+ currents in neuroblastoma cells (blocking by 6.0% at 50 µM). The compound also exhibits anti-inflammatory activity in human neutrophils by inhibiting elastase release (IC50 = 19150.0 nM) and superoxide anion generation (IC50 = 13240.0 nM). Additionally, it shows antiplasmodial activity against chloroquine-sensitive (IC50 = 47500.0 nM) and chloroquine-resistant Plasmodium falciparum strains (IC50 = 59000.0 nM), and antibacterial activity against Mycobacterium smegmatis and Bacillus subtilis (MIC = 100.0 µg/mL). It possesses antileishmanial and antitrypanosomal activities with IC90 values of 100.0 µg/mL for Leishmania braziliensis and Trypanosoma cruzi Tulahuen, respectively. The compound exhibits cytotoxicity against human A2780 cells (IC50 = 4.2 µg/mL) and A549 cells (IC50 > 10000.0 nM), and genotoxic effects in CHO cells, especially when combined with UV irradiation. Furthermore, Skimmianine shows immunomodulatory activity, inhibits acetylcholinesterase (AChE) (IC50 = 8.6 µg/mL), and has antiviral activity against SARS-CoV-2 (IC50 > 20000.0 nM). It also acts as an antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1) and affects the feeding deterrent activity and growth rates of insects such as Tribolium castaneum and Sitophilus zeamais on treated wheat flour..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.
Synonyms	Skimmianin, Skimmiamine, Chloroxylonine, beta-Fagarine

Chemical Properties

Molecular Weight	259.26
Formula	C₁₄H₁₃NO₄
Cas No.	83-95-4
Smiles	COC1=CC=C2C(OC)=C3C=COC3=NC2=C1OC
Relative Density.	1.26g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 5 mg/mL (19.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8571 mL	19.2857 mL	38.5713 mL	192.8566 mL
5 mM	0.7714 mL	3.8571 mL	7.7143 mL	38.5713 mL
10 mM	0.3857 mL	1.9286 mL	3.8571 mL	19.2857 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc