This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Spilanthol
Catalog No. T81117 CAS
25394-57-4
Spilanthol, an orally active compound with analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial, and insecticidal properties, facilitates the induction of cAMP, thereby inhibiting the negative regulation of the urinary concentration mechanism. It is also utilized in diuretic research [1] [4] [5].
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Spilanthol, an orally active compound with analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial, and insecticidal properties, facilitates the induction of cAMP, thereby inhibiting the negative regulation of the urinary concentration mechanism. It is also utilized in diuretic research [1] [4] [5].
In vitro
Spilanthol (50~150 μM, 24h) has no effect on the viability of A549 human lung epithelial cells [3].
In vivo
Spilanthol (1-1.875 mg/kg, IP, once) exhibited analgesic effects in male ICR mouse models induced by acetic acid writhing and capsaicin paw licking [2]. Spilanthol (30 mg/kg, orally, once daily for four days) protected against intestinal mucositis in Swiss mice induced by 5-Fluorouracil [4]. Additionally, Spilanthol (800 mg/kg, orally, administered once) acted as a diuretic in adult male C57BL/6J mice [5].
Molecular Weight
221.34
Formula
C14H23NO
CAS No.
25394-57-4
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.