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JI6

Catalog No. T64370 CAS 856436-16-3

Synonyms: JAK3 Inhibitor VI

JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ∼500 and ∼250 nM, respectively. JI6 has research value in acute myeloid leukemia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

JI6, CAS 856436-16-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 379.00
10 mg	In stock	$ 568.00
25 mg	In stock	$ 913.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,680.00
500 mg	In stock	$ 3,360.00

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Purity: 97.74%

Biological Description

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Description	JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ∼500 and ∼250 nM, respectively. JI6 has research value in acute myeloid leukemia.
In vitro	JI6 (3-1000 nM; 1-4 days) inhibits MV4-11 cell viability in a dose-dependent manner with IC50 of ∼25 nM. JI6 (1-2000 nM; 48 h) potently inhibits the viability of HCD-57 cells expressing FLT3-ITD, FLT3-D835Y and FLT3-D835H with IC50 of ∼40 nM. JI6 has no effect on the parent HCD-57 or JAK2V617F expressing cells. JI6 (100-500 nM; 24 h) induce apoptosis and cell cycle arrest in HCD-57 cells expressing FLT3-ITD and FLT3-D835Y. JI6 (50-500 nM; 3 h) inhibits phosphorylation of FLT3, ERK and Akt in HCD-57 cells expressing FLT3-ITD and FLT3-D835Y[1].
In vivo	JI6 (15 mg/kg; i.p. daily for 3 weeks) inhibits the proliferation of HCD-57 expressing FLT3-D835Y in SCID mouse and prolong the survival. JI6 (25 mg/kg; p.o. daily for 3 weeks) inhibits myeloproliferative phenotype in FLT3-ITD knock-in mice. JI6 (100 mg/kg; a single i.p.) significantly inhibits FLT3 phosphorylation and downstream signal transduction in mice expressing FLT3-D835Y[1].

Synonyms	JAK3 Inhibitor VI
Molecular Weight	383.42
Formula	C19H17N3O4S
CAS No.	856436-16-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.5 mg/mL (11.7 mM), Sonification is recommended.

References and Literature

1. Chen Y, et, al. Identification of an orally available compound with potent and broad FLT3 inhibition activity. Oncogene. 2016 Jun 9;35(23):2971-8.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JI6 856436-16-3 Angiogenesis Tyrosine Kinase/Adaptors FLT JI-6 JAK3 Inhibitor VI JI 6 inhibitor inhibit

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