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L-Thyroxine sodium

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Catalog No. T22355Cas No. 55-03-8
Alias L-T4 sodium, LT4 sodium, Levothyroxine sodium

L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.

L-Thyroxine sodium
Other Forms of L-Thyroxine sodium:

L-Thyroxine sodium

🥰Excellent
Purity: 98.74%
Catalog No. T22355Alias L-T4 sodium, LT4 sodium, Levothyroxine sodiumCas No. 55-03-8
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 mg$47In StockIn Stock
1 g$62In StockIn Stock
1 mL x 10 mM (in DMSO)$52In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.74%
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Product Introduction

Bioactivity
Description
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
In vitro
evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR[1]
Cell Research
Cell lines: LS180V cells. Concentrations: 100 nM and 100μM. Incubation Time: 72 h. Method: LS180V cells are induced for 72 h with two l-T4 concentrations of 100 nM and 100 μM.
Animal Research
Animal Models: SD rats. Dosages: 20 μg/kg/day and 100 μg/kg/day. Administration: i.p.
SynonymsL-T4 sodium, LT4 sodium, Levothyroxine sodium
Chemical Properties
Molecular Weight798.85
FormulaC15H10I4NO4.Na
Cas No.55-03-8
Smiles[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 27.5 mg/mL (34.42 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.5 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2518 mL6.2590 mL12.5180 mL62.5900 mL
5 mM0.2504 mL1.2518 mL2.5036 mL12.5180 mL
10 mM0.1252 mL0.6259 mL1.2518 mL6.2590 mL
20 mM0.0626 mL0.3129 mL0.6259 mL3.1295 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Thyroidhormonereceptor(THR)ThyroidhormonereceptorThyroid hormone receptor(THR)Thyroid hormone receptorThyroid Hormone ReceptorThyroid HormoneTHRT-4T 4L-Thyroxine sodiumLThyroxine sodiumL-ThyroxineLevothyroxineL Thyroxine sodiumInhibitorinhibit
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