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Anti-Phospho-p53 (S392) Antibody (2F452)
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Catalog No. TMAC-03244
Anti-Phospho-p53 (S392) Antibody (2F452) is a Rabbit antibody targeting Phospho-p53 (S392). Anti-Phospho-p53 (S392) Antibody (2F452) can be used in WB,IHC,IP,IF.
Anti-Phospho-p53 (S392) Antibody (2F452)
Anti-Phospho-p53 (S392) Antibody (2F452)
😃Good
Catalog No. TMAC-03244
Anti-Phospho-p53 (S392) Antibody (2F452) is a Rabbit antibody targeting Phospho-p53 (S392). Anti-Phospho-p53 (S392) Antibody (2F452) can be used in WB,IHC,IP,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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| Description | Anti-Phospho-p53 (S392) Antibody (2F452) is a Rabbit antibody targeting Phospho-p53 (S392). Anti-Phospho-p53 (S392) Antibody (2F452) can be used in WB,IHC,IP,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000-5000; IHC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | p53 is a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers. Phosphorylation of p53 at residue Thr 155 is mediated by the COP9 signalosome (CSN) and targets p53 to ubiquitin-26S Proteasome-dependent degradation. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human p53 around the phosphorylation site of Ser392 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 53 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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