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Anti-Phospho-p53 (S392) Antibody (2F452)

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Catalog No. TMAC-03244

Anti-Phospho-p53 (S392) Antibody (2F452) is a Rabbit antibody targeting Phospho-p53 (S392). Anti-Phospho-p53 (S392) Antibody (2F452) can be used in WB,IHC,IP,IF.

Anti-Phospho-p53 (S392) Antibody (2F452)

Anti-Phospho-p53 (S392) Antibody (2F452)

😃Good
Catalog No. TMAC-03244
Anti-Phospho-p53 (S392) Antibody (2F452) is a Rabbit antibody targeting Phospho-p53 (S392). Anti-Phospho-p53 (S392) Antibody (2F452) can be used in WB,IHC,IP,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4977-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-p53 (S392) Antibody (2F452) is a Rabbit antibody targeting Phospho-p53 (S392). Anti-Phospho-p53 (S392) Antibody (2F452) can be used in WB,IHC,IP,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:1000-5000; IHC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research Backgroundp53 is a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers. Phosphorylation of p53 at residue Thr 155 is mediated by the COP9 signalosome (CSN) and targets p53 to ubiquitin-26S Proteasome-dependent degradation.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human p53 around the phosphorylation site of Ser392
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 53 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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