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Anti-IFNAR2 Antibody (6X418)
😃Good
Catalog No. TMAY-00684
Alias interferon (α, β and ω) receptor 2, interferon (α, β and Ω) receptor 2, interferon (alpha, beta and omega) receptor 2, IFN-α-REC, IFN-R, IFNARB, IFN-alpha-REC, IFNABR
Anti-IFNAR2 Antibody (6X418) is a Mouse antibody targeting IFNAR2. Anti-IFNAR2 Antibody (6X418) can be used in WB.
Anti-IFNAR2 Antibody (6X418)
Anti-IFNAR2 Antibody (6X418)
😃Good
Catalog No. TMAY-00684Alias interferon (α, β and ω) receptor 2, interferon (α, β and Ω) receptor 2, interferon (alpha, beta and omega) receptor 2, IFN-α-REC, IFN-R, IFNARB, IFN-alpha-REC, IFNABR
Anti-IFNAR2 Antibody (6X418) is a Mouse antibody targeting IFNAR2. Anti-IFNAR2 Antibody (6X418) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: WB Reactivity: Human |
| Alias | interferon (α, β and ω) receptor 2, interferon (α, β and Ω) receptor 2, interferon (alpha, beta and omega) receptor 2, IFN-α-REC, IFN-R, IFNARB, IFN-alpha-REC, IFNABR |
| Ig Type | Mouse IgG1 |
| Clone | 6X418 |
| Reactivity | Human |
| Verified Activity | Anti-IFNaR2 mouse monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell Lysate. -Lane B: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:57 kDa. -Observed band size:37 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFNAR2 (rh IFNAR2; TMPY-01642; NP_997468.1; Met1-Lys243). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IFNAR2 protein (TMPY-01642) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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