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Ionomycin

Catalog No. T7285 CAS 56092-81-0

Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).

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Ionomycin, CAS 56092-81-0

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1 mg	In stock	$ 196.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).
In vitro	Ionomycin (2 μM) induced cell death in LCLC 103H cells, derived from a human large cell lung carcinoma, by inducing calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway [2].Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[3].

Molecular Weight	709.01
Formula	C41H72O9
CAS No.	56092-81-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 90.0 mg/mL (126.9 mM), Sonication is recommended.

DMSO: 90.0 mg/mL (126.9 mM), Sonication is recommended.

References and Literature

1. Lautens M, et al. Total synthesis of ionomycin using ring-opening strategies. Org Lett. 2002 May 30;4(11):1879-82. 2. Assfalg-Machleidt I,et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26. 3. Uwada J, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.

Related compound libraries

This product is contained In the following compound libraries：

Rare Natural Compound Library

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Keywords

Ionomycin 56092-81-0 Membrane transporter/Ion channel Metabolism Calcium Channel inhibitor inhibit

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