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Succinylsulfathiazole

Name: Succinylsulfathiazole
Brand: TargetMol
SKU: T0749
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0749Cas No. 116-43-8

Alias Succinylsulphathiazole

Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide. An ultra long-acting drug.

Succinylsulfathiazole

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Purity: 98.77%

Catalog No. T0749Alias SuccinylsulphathiazoleCas No. 116-43-8

Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide. An ultra long-acting drug.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$40	-	In Stock
10 g	$56	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.77%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Succinylsulfathiazole AI Summary

Succinylsulfathiazole exhibits multiple bioactivities across various biological assays. It acts as a potent agonist of the Thyroid Stimulating Hormone Receptor with a potency of 15848.9 nM, leading to increased intracellular cAMP concentrations. Additionally, it enhances SMN2 splice variant expression (35481.3 nM) and modulates Lamin A splicing with high potency (3.2 nM). It also has activity in the S16 Schwann cell PMP22 intronic element firefly luciferase assay (43.6 nM) and is active in identifying gametocytocidal compounds (3162.3 nM). In Ebola virus assays, it shows significant activity with varying AC50 values (19.95 µM to 39810.7 nM). Succinylsulfathiazole demonstrates a moderate to high potential for drug absorption in humans, evidenced by a human intestinal absorption log10 value of 1.176. It significantly inhibits OATP1B1 and OATP1B3 transporters, with inhibition percentages of 92.68% and 71.32% at 10 µM, respectively. However, it shows negligible inhibition of the human BSEP (IC50 > 1,000,000 nM), highlighting a lack of effectiveness in this pathway. In terms of antiviral activity, Succinylsulfathiazole shows limited effectiveness against SARS-CoV-2. It exhibited low cytotoxicity inhibition in Vero E6 cells with a low inhibition index (0.08254) and a modest inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM (13.03%). Additionally, in Caco-2 cells, it slightly inhibited SARS-CoV-2-induced cytotoxicity (-0.46% inhibition at 10 µM). In VERO-6 cells, it showed minimal inhibition (0.07% at 10 µM) and an IC50 value of greater than 20000.0 nM for cytotoxicity inhibition, indicating lower antiviral potency. Lastly, Succinylsulfathiazole exhibits HDAC6 inhibitory activity with a 34.38% inhibition using a commercial peptide substrate and 3.9% using a custom peptide substrate, indicating a variance in effectiveness based on the substrate used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide. An ultra long-acting drug.
Synonyms	Succinylsulphathiazole

Chemical Properties

Molecular Weight	355.39
Formula	C₁₃H₁₃N₃O₅S₂
Cas No.	116-43-8
Smiles	OC(=O)CCC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1
Relative Density.	1.4807 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (168.83 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8138 mL	14.0691 mL	28.1381 mL	140.6905 mL
5 mM	0.5628 mL	2.8138 mL	5.6276 mL	28.1381 mL
10 mM	0.2814 mL	1.4069 mL	2.8138 mL	14.0691 mL
20 mM	0.1407 mL	0.7035 mL	1.4069 mL	7.0345 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL	2.8138 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc