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Chromocarb

Name: Chromocarb
Brand: TargetMol
SKU: T0259
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0259Cas No. 4940-39-0

Alias Chromone-2-carboxylic acid, Chromocarbe

Chromocarb (Chromone-2-carboxylic acid) is a vascular protective agent used to treat venous disorders and microvascular affections.

Chromocarb

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Purity: 99.91%

Catalog No. T0259Alias Chromone-2-carboxylic acid, ChromocarbeCas No. 4940-39-0

Chromocarb (Chromone-2-carboxylic acid) is a vascular protective agent used to treat venous disorders and microvascular affections.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Chromocarb (Chromone-2-carboxylic acid) is a vascular protective agent used to treat venous disorders and microvascular affections.
In vitro	Rats treated orally with Chromocarb exhibited a significant reduction in vascular wall degradation induced by intravenous collagenase. Chromocarb treatment led to a decreased increase in BBB (blood-brain barrier) permeability, accelerated recovery, lower hydroxyproline levels in cerebrospinal fluid, and a lesser decline in collagen content within the cerebral capillary basement membranes. Furthermore, at a dose of 50 mg/kg, Chromocarb was more effective than vitamin C at preventing the oxidation of reduced glutathione in the blood.
Synonyms	Chromone-2-carboxylic acid, Chromocarbe

Chemical Properties

Molecular Weight	190.15
Formula	C₁₀H₆O₄
Cas No.	4940-39-0
Smiles	OC(=O)C1=CC(=O)C2=C(O1)C=CC=C2
Relative Density.	1.493 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (262.95 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2590 mL	26.2950 mL	52.5901 mL	262.9503 mL
5 mM	1.0518 mL	5.2590 mL	10.5180 mL	52.5901 mL
10 mM	0.5259 mL	2.6295 mL	5.2590 mL	26.2950 mL
20 mM	0.2630 mL	1.3148 mL	2.6295 mL	13.1475 mL
50 mM	0.1052 mL	0.5259 mL	1.0518 mL	5.2590 mL
100 mM	0.0526 mL	0.2630 mL	0.5259 mL	2.6295 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc