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Anti-ENPP2 Antibody (5B899) is a Mouse antibody targeting ENPP2. Anti-ENPP2 Antibody (5B899) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $198 | 7-10 days |
Description | Anti-ENPP2 Antibody (5B899) is a Mouse antibody targeting ENPP2. Anti-ENPP2 Antibody (5B899) can be used in ELISA. |
Alias | PDNP2, PD-Iα, PD-IALPHA, NPP2, LysoPLD, ectonucleotide pyrophosphatase/phosphodiesterase 2, AUTOTAXIN, ATX-X, ATX |
Ig Type | Monoclonal Mouse IgG2b |
Clone | 5B899 |
Reactivity | Human |
Application | ELISA |
Recommended Dose | ELISA: 1:1000-1:2000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Autotaxin/ENPP2 (rh Autotaxin/ENPP2; TMPY-02778; AAH34961.1; Asp49-Ile863). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human Autotaxin/ENPP2 Protein (TMPY-02778) |
Antigen Species | Human |
Biology Area | Phosphatases and Regulators |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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