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Tavapadon

Name: Tavapadon
Brand: TargetMol
SKU: T16999
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16999Cas No. 1643489-24-0

Alias PF-6649751, CVL-751

Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.

Tavapadon

🥰Excellent

Purity: 99.8%

Catalog No. T16999Alias PF-6649751, CVL-751Cas No. 1643489-24-0

Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	In Stock	In Stock
5 mg	$178	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$528	In Stock	In Stock
50 mg	$743	In Stock	In Stock
100 mg	$987	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.8%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
In vivo	Administered subcutaneously to captive-bred macaques, Tavapadon at a dose of 0.1 mg/kg results in a mean maximal unbound plasma concentration of 8 nM, with peak levels reached 3 hours post-administration. At lower doses (0.02 and 0.04 mg/kg; s.c.), only the 0.04 mg/kg dosage significantly increases locomotor activity, while the 0.02 mg/kg dosage exhibits minimal to no impact. Furthermore, a 0.04 mg/kg dose of Tavapadon not only enhances locomotor activity but also notably improves parkinsonian disability scores, with maximum benefits observed at 110 minutes after administration. Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) demonstrate a statistically significant improvement in locomotor activity compared to a vehicle control [1].
Synonyms	PF-6649751, CVL-751

Chemical Properties

Molecular Weight	391.34
Formula	C₁₉H₁₆F₃N₃O₃
Cas No.	1643489-24-0
Smiles	CC1=C(C=CC(OC2=C(C(F)(F)F)C=CC=N2)=C1)C3=C(C)C(=O)NC(=O)N3C
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (153.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5553 mL	12.7766 mL	25.5532 mL	127.7661 mL
5 mM	0.5111 mL	2.5553 mL	5.1106 mL	25.5532 mL
10 mM	0.2555 mL	1.2777 mL	2.5553 mL	12.7766 mL
20 mM	0.1278 mL	0.6388 mL	1.2777 mL	6.3883 mL
50 mM	0.0511 mL	0.2555 mL	0.5111 mL	2.5553 mL
100 mM	0.0256 mL	0.1278 mL	0.2555 mL	1.2777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc