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Anti-CD22-NMS249
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Catalog No. T9901A-233 Copy Product Info
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Anti-CD22-NMS249 is an antibody-drug conjugate (ADC) that targets CD22, comprising the humanized anti-CD22 antibody Pinatuzumab, a cleavable linker (Mc-VC-PAB), and the effective payload of DNA topoisomerase II inhibitor PNU-159682. This compound is utilized in the study of non-Hodgkin lymphoma (NHL).
Anti-CD22-NMS249
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
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| Description | Anti-CD22-NMS249 is an antibody-drug conjugate (ADC) that targets CD22, comprising the humanized anti-CD22 antibody Pinatuzumab, a cleavable linker (Mc-VC-PAB), and the effective payload of DNA topoisomerase II inhibitor PNU-159682. This compound is utilized in the study of non-Hodgkin lymphoma (NHL). |
| In vitro | Anti-CD22-NMS249 effectively inhibits the proliferation of non-Hodgkin lymphoma (NHL) cell lines, displaying IC50 values of 0.058 μg/mL for BJAB.Luc, 0.030 μg/mL for Granta-519, 0.0221 μg/mL for SuDHL4.Luc, and 0.010 μg/mL for WSU-DLCL2. |
| In vivo | The chemical compound Anti-CD22-NMS249 administered as a single intravenous injection at dosages ranging from 0.5 to 2 mg/kg, induced tumor stasis in four different xenograft models. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Target | CD22 |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Anti-CD22-NMS249 in vivo | Anti-CD22-NMS249 in vitro
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