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TargetMol | Compound Library

AMPK-Targeted Compound Library

Catalog No. L1120

AMPK(Adenosine 5'-monophosphate (AMP)-activated protein kinase) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Binding of AMP causes allosteric activation of the enzyme and binding of either AMP or ADP promotes and maintains the phosphorylation of threonine 172 within the activation loop of the kinase. AMP-activated protein kinase (AMPK) AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases including type 2 diabetes and, more recently, cancer. AMPK activity is prominent in regulation of glucose, lipid, and proteins metabolism as well as mitochondrial biogenesis and autophagy. Activation of AMPK in the liver decrease blood glucose and in skeletal muscles stimulates glucose uptake independently of insulin through modulation of activity of several downstream substrates. Activation of AMPK inhibits synthesis and induces oxidation of fatty acids, which may reduce ectopic lipid accumulation and improve insulin action. The enzyme activation promotes cardiovascular homeostasis by ensuring optimum redox balance of heart and vascular tissue. In addition, AMPK signaling may link to cancer development via regulation of checkpoints of cell cycle. TargetMol's AMPK-Targeted Compound Library containing 80 compounds targeting AMPK can be used for research in AMPK signaling pathway and its dysfunction-related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1120

AMPK-Targeted Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Features Product Features

  • Quantity:80 well-chosen unique AMPK-targeted small molecules;
  • Detailed compound information with structure, target, IC50, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;
  • All compounds are in stock;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

AMPK
Autophagy
Apoptosis
Akt
Mitophagy
PPAR
ERK
Cytochromes P450
Antibacterial
Endogenous Metabolite
NF-κB
HIV Protease
JNK
Parasite
Calcium Channel
Topoisomerase
COX
mTOR
TGF-beta/Smad
transporter
Influenza Virus
STAT
Potassium Channel
AChR
ADC Cytotoxin
Chloride channel
NOS
NPC1L1
Src
Integrin
YAP
PI3K
Adenosine Receptor
BACE
PERK
Tie-2
Virus Protease
HBV
Wnt/beta-catenin
Serine Protease
Glucokinase
Caspase
PKC
SIK
E1/E2/E3 Enzyme
LDL
CDK
Fatty Acid Synthase
JAK
PDGFR
HSV
Cholinesterase (ChE)
MMP
Aurora Kinase
CaMK
ATP Citrate Lyase
DNA/RNA Synthesis
Beta-Secretase
Prostaglandin Receptor
Sirtuin
IκB/IKK
HDAC
HIF
FGFR
MEK
c-RET
FLT
Tyrosinase
Antibiotic

Keywords