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TargetMol | Compound Library

AMPK-Targeted Compound Library

Catalog No. L1120

AMPK(Adenosine 5‘-monophosphate (AMP)-activated protein kinase) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Binding of AMP causes allosteric activation of the enzyme and binding of either AMP or ADP promotes and maintains the phosphorylation of threonine 172 within the activation loop of the kinase. AMP-activated protein kinase (AMPK) AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases including type 2 diabetes and, more recently, cancer. AMPK activity is prominent in regulation of glucose, lipid, and proteins metabolism as well as mitochondrial biogenesis and autophagy. Activation of AMPK in the liver decrease blood glucose and in skeletal muscles stimulates glucose uptake independently of insulin through modulation of activity of several downstream substrates. Activation of AMPK inhibits synthesis and induces oxidation of fatty acids, which may reduce ectopic lipid accumulation and improve insulin action. The enzyme activation promotes cardiovascular homeostasis by ensuring optimum redox balance of heart and vascular tissue. In addition, AMPK signaling may link to cancer development via regulation of checkpoints of cell cycle. TargetMol’s AMPK-Targeted Compound Library containing 80 compounds targeting AMPK can be used for research in AMPK signaling pathway and its dysfunction-related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1120

AMPK-Targeted Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Features Product Features

  • Quantity:80 well-chosen unique AMPK-targeted small molecules;
  • Detailed compound information with structure, target, IC50, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;
  • All compounds are in stock;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

AMPK
Autophagy
Apoptosis
Akt
Mitophagy
PPAR
Antibacterial
Endogenous Metabolite
ERK
NF-κB
P450
AChR
Calcium Channel
COX
HIV Protease
Influenza Virus
JNK
mTOR
Parasite
Potassium Channel
STAT
TGF-beta/Smad
transporter
AChE
Adenosine Receptor
Antibiotic
ATP Citrate Lyase
Aurora Kinase
BACE
Beta-Secretase
CaMK
Caspase
CDK
Chloride channel
c-RET
DNA/RNA Synthesis
E1/E2/E3 Enzyme
Fatty Acid Synthase
FGFR
FLT
Glucokinase
HBV
HDAC
HIF
HSV
Integrin
IκB/IKK
JAK
LDL
MEK
MMP
NOS
NPC1L1
PDGFR
PERK
PI3K
PKC
Prostaglandin Receptor
Serine Protease
SIK
Sirtuin
Src
Tie-2
Topoisomerase
Tyrosinase
Virus Protease
Wnt/beta-catenin
YAP

Keywords