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Anti-CIP2A/p90 Autoantigen Polyclonal Antibody
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Catalog No. TMAB-04358
Anti-CIP2A/p90 Autoantigen Polyclonal Antibody is a Rabbit antibody targeting CIP2A/p90 Autoantigen. Anti-CIP2A/p90 Autoantigen Polyclonal Antibody can be used in ICC/IF,FCM.
Anti-CIP2A/p90 Autoantigen Polyclonal Antibody
Anti-CIP2A/p90 Autoantigen Polyclonal Antibody
😃Good
Catalog No. TMAB-04358
Anti-CIP2A/p90 Autoantigen Polyclonal Antibody is a Rabbit antibody targeting CIP2A/p90 Autoantigen. Anti-CIP2A/p90 Autoantigen Polyclonal Antibody can be used in ICC/IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CIP2A/p90 Autoantigen Polyclonal Antibody is a Rabbit antibody targeting CIP2A/p90 Autoantigen. Anti-CIP2A/p90 Autoantigen Polyclonal Antibody can be used in ICC/IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Cow,Rabbit) |
| Application | |
| Recommended Dose | ICC/IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region. |
| Tissue Specificity | Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. |
| Immunogen | KLH conjugated synthetic peptide: human p90 Autoantigen |
| Antigen Species | Human |
| Gene Name | CIP2A |
| Gene ID | |
| Protein Name | Protein CIP2A |
| Uniprot ID |
| Molecular Weight | Theoretical: 100 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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