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Lonazolac

Name: Lonazolac
Brand: TargetMol
SKU: T50025
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50025Cas No. 53808-88-1

Lonazolac is a nonsteroidal anti-inflammatory drug[1].

Lonazolac

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Purity: 99.40%

Catalog No. T50025Cas No. 53808-88-1

Lonazolac is a nonsteroidal anti-inflammatory drug[1].

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$52	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$298	In Stock	In Stock
200 mg	$449	-	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.40%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Lonazolac AI Summary

Lonazolac exhibits bioactivity as an inhibitor across several biochemical targets. It is a potent inhibitor of Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 28183.8 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 44668.4 nM, and Polymerase Iota at 56234.1 nM. It induces DNA re-replication in both MCF 10a normal breast cells (18356.4 nM) and SW480 colon adenocarcinoma cells (7307.8 nM). Additionally, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 33498.3 nM in the absence of CPT and 29855.4 nM in the presence of CPT, and it shows inhibitory action in the PTHR assay at 39810.7 nM. Furthermore, Lonazolac blocks Ebola Virus entry with AC50 values ranging from 3.981 μM to 3981.1 nM. It demonstrates moderate hepatotoxicity, with acute liver toxicity noted during clinical trials, but it does not cause cholestatic liver toxicity. It also has a high plasma protein binding potential (99.82%), influencing its distribution and bioavailability. Lonazolac shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells, with an IC50 value greater than 19952.62 nM after 48 hours. Binding assays reveal that Lonazolac generally exhibits weak or negligible bioactivity (AC50 values >30000.0 nM) in most receptor and transporter interactions, with notable moderate binding affinity to human DRD2 (AC50 of 830.0 nM). Thus, despite its various inhibitory effects, it does not display significant bioactivity in some tested interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Lonazolac is a nonsteroidal anti-inflammatory drug[1].

Chemical Properties

Molecular Weight	312.75
Formula	C₁₇H₁₃ClN₂O₂
Cas No.	53808-88-1
Smiles	C(C(O)=O)C=1C(=NN(C1)C2=CC=CC=C2)C3=CC=C(Cl)C=C3
Relative Density.	1.3g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (159.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1974 mL	15.9872 mL	31.9744 mL	159.8721 mL
5 mM	0.6395 mL	3.1974 mL	6.3949 mL	31.9744 mL
10 mM	0.3197 mL	1.5987 mL	3.1974 mL	15.9872 mL
20 mM	0.1599 mL	0.7994 mL	1.5987 mL	7.9936 mL
50 mM	0.0639 mL	0.3197 mL	0.6395 mL	3.1974 mL
100 mM	0.0320 mL	0.1599 mL	0.3197 mL	1.5987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc