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Spironolactone

Name: Spironolactone
Brand: TargetMol
SKU: T0476
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0476Cas No. 52-01-7

Alias SC9420, Abbolactone

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Spironolactone

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Purity: 99.87%

Catalog No. T0476Alias SC9420, AbbolactoneCas No. 52-01-7

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$33	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.87%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
Targets&IC50	Androgen receptor:77 nM
In vitro	Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM.
In vivo	Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM.
Synonyms	SC9420, Abbolactone

Chemical Properties

Molecular Weight	416.57
Formula	C₂₄H₃₂O₄S
Cas No.	52-01-7
Smiles	C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
Relative Density.	1.24g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20.8 mg/mL (49.93 mM), Sonication is recommended.

DMSO: 45 mg/mL (108.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4006 mL	12.0028 mL	24.0056 mL	120.0278 mL
5 mM	0.4801 mL	2.4006 mL	4.8011 mL	24.0056 mL
10 mM	0.2401 mL	1.2003 mL	2.4006 mL	12.0028 mL
20 mM	0.1200 mL	0.6001 mL	1.2003 mL	6.0014 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0480 mL	0.2401 mL	0.4801 mL	2.4006 mL
100 mM	0.0240 mL	0.1200 mL	0.2401 mL	1.2003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc