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Spironolactone

Name: Spironolactone
Brand: TargetMol
SKU: T0476
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0476Cas No. 52-01-7

Alias SC9420, Abbolactone

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Spironolactone

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Purity: 99.87%

Catalog No. T0476Alias SC9420, AbbolactoneCas No. 52-01-7

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$33	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.87%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
Targets&IC50	Androgen receptor:77 nM
In vitro	Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM.
In vivo	Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM.
Synonyms	SC9420, Abbolactone

Chemical Properties

Molecular Weight	416.57
Formula	C₂₄H₃₂O₄S
Cas No.	52-01-7
Smiles	C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
Relative Density.	1.24g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20.8 mg/mL (49.93 mM), Sonication is recommended.

DMSO: 250 mg/mL (600.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4006 mL	12.0028 mL	24.0056 mL	120.0278 mL
5 mM	0.4801 mL	2.4006 mL	4.8011 mL	24.0056 mL
10 mM	0.2401 mL	1.2003 mL	2.4006 mL	12.0028 mL
20 mM	0.1200 mL	0.6001 mL	1.2003 mL	6.0014 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0480 mL	0.2401 mL	0.4801 mL	2.4006 mL
100 mM	0.0240 mL	0.1200 mL	0.2401 mL	1.2003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc