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Caryophyllene oxide

Name: Caryophyllene oxide
Brand: TargetMol
SKU: T2724
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2724Cas No. 1139-30-6

Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity.

Caryophyllene oxide

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Purity: 99.87%

Catalog No. T2724Cas No. 1139-30-6

Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$41	In Stock	In Stock
500 mg	$89	In Stock	In Stock
1 g	$129	In Stock	-
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Caryophyllene oxide AI Summary

Caryophyllene oxide exhibits a range of biological activities. It demonstrates significant antispasmodic properties, inhibiting K+-induced contraction in rabbit jejunum (31.6% inhibition at 1 mg/ml), and various induced contractions in rat ileum with IC50 values of 23.78 nM (barium chloride), 30.0 nM (histamine), 34.4 nM (acetylcholine), and 1.36 nM (spontaneous contraction). Its low IC50 ratio to papaverine (0.071) indicates potent activity. Additionally, Caryophyllene oxide has insecticidal efficacy against acaricide-susceptible two-spotted spider mites, with an LC50 value exceeding 500 μg/cm³ in a vapor-phase bioassay. It shows cytotoxic activity against human HL cells, achieving 106.9% activity at 50 μM after 72 hours, and possesses antichlamydial properties against Chlamydia pneumoniae K7, inhibiting 35.7% at 50 μM after 70 hours. Moreover, it exhibits antagonist activity at human ORAI1 and TRPV1 channels expressed in HEK293T cells, reducing capsaicin-induced inward currents by 44.0% and 45.0%, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity.

Chemical Properties

Molecular Weight	220.35
Formula	C₁₅H₂₄O
Cas No.	1139-30-6
Smiles	C[C@@]12CC[C@@H]3[C@H](CC3(C)C)C(=C)CC[C@H]1O2
Relative Density.	0.96

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (283.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5382 mL	22.6912 mL	45.3823 mL	226.9117 mL
5 mM	0.9076 mL	4.5382 mL	9.0765 mL	45.3823 mL
10 mM	0.4538 mL	2.2691 mL	4.5382 mL	22.6912 mL
20 mM	0.2269 mL	1.1346 mL	2.2691 mL	11.3456 mL
50 mM	0.0908 mL	0.4538 mL	0.9076 mL	4.5382 mL
100 mM	0.0454 mL	0.2269 mL	0.4538 mL	2.2691 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc