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Ethyl Orsellinate

Name: Ethyl Orsellinate
Brand: TargetMol
SKU: T2784
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2784Cas No. 2524-37-0

Alias Orsellinic acid ethyl ester

Ethyl Orsellinate (Orsellinic acid ethyl ester) is a phenolic acid, extracted from lichens.

Ethyl Orsellinate

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Purity: 97.53%

Catalog No. T2784Alias Orsellinic acid ethyl esterCas No. 2524-37-0

Ethyl Orsellinate (Orsellinic acid ethyl ester) is a phenolic acid, extracted from lichens.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.53%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Ethyl Orsellinate AI Summary

Ethyl Orsellinate demonstrates multifaceted bioactivities, including the enhancement of SMN2 splice variant expression (potency of 25118.9 nM), inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1) (potency of 1000.0 nM), and activation as well as inhibition of Cytochrome P450 3A4 (potency of 25118.9 nM). It also inhibits Polymerase Iota (potency of 14125.4 nM) and induces DNA re-replication in SW480 colon adenocarcinoma cells (potency of 366.3 nM). Additionally, it inhibits the binding or cellular entry of Lassa Virus (potency of 17782.8 nM). The compound exhibits significant antifungal activity against fungi like Pythium debaryanum, Pythium aphanidermatum, Fusarium udum, Rhizoctonia bataticola, Rhizoctonia solani, and Athelia rolfsii, showing growth inhibition at various concentrations (62.5, 125, and 250 µg/ml) with ED50 values indicating its potency. Moreover, Ethyl Orsellinate inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 116.8% and 105.83% respectively at a concentration of 10 µM. It also exhibits antiviral activity against SARS-CoV-2, inhibiting its induced cytotoxicity in VERO-6 cells with an IC50 value exceeding 20000.0 nM, highlighting its potential as an antiviral therapeutic candidate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethyl Orsellinate (Orsellinic acid ethyl ester) is a phenolic acid, extracted from lichens.
Synonyms	Orsellinic acid ethyl ester

Chemical Properties

Molecular Weight	196.2
Formula	C₁₀H₁₂O₄
Cas No.	2524-37-0
Smiles	CCOC(=O)C1=C(O)C=C(O)C=C1C
Relative Density.	1.2166 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (305.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0968 mL	25.4842 mL	50.9684 mL	254.8420 mL
5 mM	1.0194 mL	5.0968 mL	10.1937 mL	50.9684 mL
10 mM	0.5097 mL	2.5484 mL	5.0968 mL	25.4842 mL
20 mM	0.2548 mL	1.2742 mL	2.5484 mL	12.7421 mL
50 mM	0.1019 mL	0.5097 mL	1.0194 mL	5.0968 mL
100 mM	0.0510 mL	0.2548 mL	0.5097 mL	2.5484 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc