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KB-0742 dihydrochloride

Name: KB-0742 dihydrochloride
Brand: TargetMol
SKU: T9446
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9446Cas No. 2416874-75-2

KB-0742 dihydrochloride is a potent, selective, and orally administered inhibitor of CDK9.

KB-0742 dihydrochloride

🥰Excellent

Purity: 99.79%

Catalog No. T9446Cas No. 2416874-75-2

KB-0742 dihydrochloride is a potent, selective, and orally administered inhibitor of CDK9.

Pack Size	Price	Availability
1 mg	$97	In Stock
2 mg	$146	In Stock
5 mg	$247	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$262	In Stock

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Batch Information

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Purity:99.79%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	KB-0742 dihydrochloride is a potent, selective, and orally administered inhibitor of CDK9.
Targets&IC50	CDK9-CyclinT1:6 nM (IC50)

Chemical Properties

Molecular Weight	360.33
Formula	C₁₆H₂₇Cl₂N₅
Cas No.	2416874-75-2
Smiles	Cl.Cl.CCC(CC)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (166.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7752 mL	13.8762 mL	27.7523 mL	138.7617 mL
5 mM	0.5550 mL	2.7752 mL	5.5505 mL	27.7523 mL
10 mM	0.2775 mL	1.3876 mL	2.7752 mL	13.8762 mL
20 mM	0.1388 mL	0.6938 mL	1.3876 mL	6.9381 mL
50 mM	0.0555 mL	0.2775 mL	0.5550 mL	2.7752 mL
100 mM	0.0278 mL	0.1388 mL	0.2775 mL	1.3876 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc