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Anti-Nicastrin Polyclonal Antibody
Catalog No. TMAB-09472 Copy Product Info
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Anti-Nicastrin Polyclonal Antibody is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Polyclonal Antibody can be used in WB.
Anti-Nicastrin Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-09472
Anti-Nicastrin Polyclonal Antibody is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Polyclonal Antibody can be used in WB.
Anti-Nicastrin Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
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| Description | Anti-Nicastrin Polyclonal Antibody is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Pig,Cow,Horse) |
| Verified Activity | Sample: Lane 1: Human Jurkat cell lysates Lane 2: Human HepG2 cell lysates Lane 3: Human HeLa cell lysates Lane 4: Human HL-60 cell lysates Lane 5: Human SH-SY5Y cell lysates Primary: Anti-Nicastrin (TMAB-09472) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 75 kDa Observed band size: 110 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Widely expressed. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the ∫-Amyloid precursor protein (∫APP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of ∫APP and results in the overproduction of the neurotoxic ∫-Amyloid peptide, which results in a condition associated with Familial Alzheimer’s disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of ∫APP, which makes nicastrin an attractive potential target for modulating the production of ∫-Amyloid in patients with Alzheimer’s disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites. |
| Immunogen | KLH conjugated synthetic peptide: human Nicastrin |
| Antigen Species | Human |
| Gene Name | NCSTN |
| Gene ID | |
| Protein Name | Nicastrin |
| Uniprot ID | |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. |
| Molecular Weight | Theoretical: 75 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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