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Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody

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Catalog No. TMAC-00074

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB.

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody

Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody

😃Good
Catalog No. TMAC-00074
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2167-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
AppearanceLiquid
Research BackgroundOvercoming metabolic stress is a critical step in tumor growth. Acetyl coenzyme A (acetyl-CoA) generated from glucose and acetate uptake is important for his-tone acetylation and gene expression. However, how acetyl-CoA is produced under nutritional stress is un-clear. We demonstrate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-medi-ated acetyl-CoA synthetase 2 (ACSS2) phosphoryla-tion at S659, which exposed the nuclear localization signal of ACSS2 for importin a5 binding and nuclear translocation. In the nucleus, ACSS2 binds to tran-scription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and pro-mote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis. In addition, ACSS2 S659 phosphorylation positively correlates with AMPK ac-tivity in glioma specimens and grades of glioma malig-nancy. These results underscore the significance of nuclear ACSS2-mediated histone acetylation in main-taining cell homeostasis and tumor development.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human ACSS2 around the phosphorylation site of serine 659
Antigen Species
human
Chemical Properties
Molecular WeightTheoretical: 78 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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