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Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody
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Catalog No. TMAC-00074
Alias p-ACSS2 (Ser659), p-ACSS2 (S659), ACSS2 (p-Ser659), ACSS2 (p-S659)
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB.
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody
😃Good
Catalog No. TMAC-00074Alias p-ACSS2 (Ser659), p-ACSS2 (S659), ACSS2 (p-Ser659), ACSS2 (p-S659)
Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $345 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
| Description | Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACSS2 (Ser659). Anti-Phospho-ACSS2 (Ser659) Polyclonal Antibody can be used in WB. |
| Synonyms | p-ACSS2 (Ser659), p-ACSS2 (S659), ACSS2 (p-Ser659), ACSS2 (p-S659) |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Appearance | Liquid |
| Research Background | Overcoming metabolic stress is a critical step in tumor growth. Acetyl coenzyme A (acetyl-CoA) generated from glucose and acetate uptake is important for his-tone acetylation and gene expression. However, how acetyl-CoA is produced under nutritional stress is un-clear. We demonstrate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-medi-ated acetyl-CoA synthetase 2 (ACSS2) phosphoryla-tion at S659, which exposed the nuclear localization signal of ACSS2 for importin a5 binding and nuclear translocation. In the nucleus, ACSS2 binds to tran-scription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and pro-mote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis. In addition, ACSS2 S659 phosphorylation positively correlates with AMPK ac-tivity in glioma specimens and grades of glioma malig-nancy. These results underscore the significance of nuclear ACSS2-mediated histone acetylation in main-taining cell homeostasis and tumor development. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human ACSS2 around the phosphorylation site of serine 659 |
| Antigen Species | human |
| Molecular Weight | Theoretical: 78 kDa. |
| Color | Transparent |
| Appearance | Liquid |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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