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Endovion

Name: Endovion
Brand: TargetMol
SKU: T15233
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15233Cas No. 265646-85-3

Alias NS3728

Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.

Endovion

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Purity: 98.51%

Catalog No. T15233Alias NS3728Cas No. 265646-85-3

Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.

Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$64	In Stock
25 mg	$129	In Stock
50 mg	$222	In Stock
100 mg	$355	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Batch Information

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Purity:98.51%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
Synonyms	NS3728

Chemical Properties

Molecular Weight	495.18
Formula	C₁₆H₉BrF₆N₆O
Cas No.	265646-85-3
Smiles	FC(F)(F)c1cc(NC(=O)Nc2ccc(Br)cc2-c2nn[nH]n2)cc(c1)C(F)(F)F
Relative Density.	1.791 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 120 mg/mL (242.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0195 mL	10.0973 mL	20.1947 mL	100.9734 mL
5 mM	0.4039 mL	2.0195 mL	4.0389 mL	20.1947 mL
10 mM	0.2019 mL	1.0097 mL	2.0195 mL	10.0973 mL
20 mM	0.1010 mL	0.5049 mL	1.0097 mL	5.0487 mL
50 mM	0.0404 mL	0.2019 mL	0.4039 mL	2.0195 mL
100 mM	0.0202 mL	0.1010 mL	0.2019 mL	1.0097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc