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BTB06584

Name: BTB06584
Brand: TargetMol
SKU: T1940
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1940Cas No. 219793-45-0

BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).

BTB06584

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Purity: 97.63%

Catalog No. T1940Cas No. 219793-45-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$67	In Stock	In Stock
25 mg	$88	In Stock	In Stock
50 mg	$125	In Stock	In Stock
100 mg	$225	In Stock	In Stock
200 mg	$348	In Stock	-
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.63%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
In vitro	BTB06584 restores defective hemoglobin synthesis in zebrafish pinotage (pnt) mutants without evident toxicity.
In vivo	BTB06584 inhibits F1Fo-ATPase activity in an IF1-dependent manner, does not affect ATP synthesis, and also restricts ischemia-induced damage caused by the reverse action of mitochondrial F1Fo-ATP synthase.

Chemical Properties

Molecular Weight	417.82
Formula	C₁₉H₁₂ClNO₆S
Cas No.	219793-45-0
Smiles	[O-][N+](=O)c1ccc(cc1OC(=O)c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1
Relative Density.	1.466 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 78 mg/mL (186.68 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3934 mL	11.9669 mL	23.9338 mL	119.6688 mL
5 mM	0.4787 mL	2.3934 mL	4.7868 mL	23.9338 mL
10 mM	0.2393 mL	1.1967 mL	2.3934 mL	11.9669 mL
20 mM	0.1197 mL	0.5983 mL	1.1967 mL	5.9834 mL
50 mM	0.0479 mL	0.2393 mL	0.4787 mL	2.3934 mL
100 mM	0.0239 mL	0.1197 mL	0.2393 mL	1.1967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc