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Anti-Complement C5a Antibody (4T257)
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Catalog No. TMAY-01018
Alias complement component 5
Anti-Complement C5a Antibody (4T257) is a Rabbit antibody targeting Complement C5a. Anti-Complement C5a Antibody (4T257) can be used in IHC-P.
Anti-Complement C5a Antibody (4T257)
Anti-Complement C5a Antibody (4T257)
😃Good
Catalog No. TMAY-01018Alias complement component 5
Anti-Complement C5a Antibody (4T257) is a Rabbit antibody targeting Complement C5a. Anti-Complement C5a Antibody (4T257) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Complement C5a Antibody (4T257) is a Rabbit antibody targeting Complement C5a. Anti-Complement C5a Antibody (4T257) can be used in IHC-P. |
| Alias | complement component 5 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4T257 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human C5a in human cirrhosis with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Complement C5a (rh Complement C5a; TMPY-00653; Leu679-Arg751; NP_001726.2; Leu679-Arg751). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | C5a is a protein fragment released from complement component C5. This 74 amino acid peptide in humans is generated by the cleavage of C5a convertase on the C5 α-chain during the classical, alternative, and lectin pathways of complement activation. The structure of C5a includes a core region consisting of four, anti-parallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail, and C5a is rapidly metabolised by carboxypeptidase B to a 73 amino acid low activity form, C5a des-Arg. C5a is an extremely potent proinflammatory mediator, as well as a potent chemotactic factor for neutrophils and other leukocytes. It causes histamine release, increases in vascular permeability, induces several cytokines production from leukocytes, enhances neutrophil-endothelial cell adhesion, and augments the humoral and cell-mediated immune response. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert a number of effects essential to the innate immune response, while their actions at the more recently discovered non-G protein-coupled receptor, C5L2 (or GPR77), remain unclear. The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases, making C5a inhibition an attractive therapeutic strategy. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accordingly, the anaphylatoxin C5a is implicated in a variety of diseases such as rheumatoid arthritis, systemic lupus erythematosus, reperfusion injury, Alzheimer's disease, and sepsis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Complement C5a protein (TMPY-00653) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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