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Memantine

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Catalog No. T20993Cas No. 19982-08-2

Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.

Memantine
Other Forms of Memantine:
Memantine hydrochlorideT144341100-52-1
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Memantine

🥰Excellent
Catalog No. T20993Cas No. 19982-08-2
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.
Pack SizePriceAvailabilityQuantity
5 mg$50In Stock
10 mg$70In Stock
25 mg$114In Stock
50 mg$167In Stock
100 mg$248In Stock
500 mg$535In Stock
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Batch Information

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Purity:≥98%
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COA MS HNMR

Product Introduction

Bioactivity
Description
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.
Chemical Properties
Molecular Weight179.3
FormulaC12H21N
Cas No.19982-08-2
SmilesCC12CC3CC(C)(C1)CC(N)(C3)C2
Relative Density.1.046
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (278.86 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.58 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.5772 mL27.8862 mL55.7724 mL278.8622 mL
5 mM1.1154 mL5.5772 mL11.1545 mL55.7724 mL
10 mM0.5577 mL2.7886 mL5.5772 mL27.8862 mL
20 mM0.2789 mL1.3943 mL2.7886 mL13.9431 mL
50 mM0.1115 mL0.5577 mL1.1154 mL5.5772 mL
100 mM0.0558 mL0.2789 mL0.5577 mL2.7886 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MemantineLTPIonotropic glutamate receptorsInhibitorinhibitiGluRhippocampaldiseasedepressiveAlzheimer's
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