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Memantine

Name: Memantine
Brand: TargetMol
SKU: T20993
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20993Cas No. 19982-08-2

Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.

Memantine

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Catalog No. T20993Cas No. 19982-08-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$114	In Stock	In Stock
50 mg	$167	In Stock	In Stock
100 mg	$248	In Stock	In Stock
500 mg	$535	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Appearance:Liquid

Color:Yellow

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COA MS HNMR

Product Introduction

Memantine AI Summary

Memantine exhibits a range of bioactivities across different biological targets. It acts as both an agonist and antagonist for the NFkB signaling pathway with a potency of 22.4 nM. It inhibits Cytochrome P450 enzymes including CYP2C19 with a potency of 10,000 nM, CYP2D6 with a potency of 316.2 nM, and shows considerable activity in Cytochrome panel assays for CYP2D6 (AC50 of 316.23 nM), CYP2C9 (AC50 of 19,952.62 nM), CYP1A2 (AC50 of 39,810.72 nM), and CYP2C19 (AC50 of 10,000.0 nM). Additionally, it inhibits the binding or entry of cells for the Marburg Virus with a potency of 20,587.8 nM, and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells, showing potencies of 21,136.0 nM in the absence of CPT and 33,498.3 nM in its presence..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	179.3
Formula	C₁₂H₂₁N
Cas No.	19982-08-2
Smiles	CC12CC3CC(C)(C1)CC(N)(C3)C2
Relative Density.	1.046

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1394.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5772 mL	27.8862 mL	55.7724 mL	278.8622 mL
5 mM	1.1154 mL	5.5772 mL	11.1545 mL	55.7724 mL
10 mM	0.5577 mL	2.7886 mL	5.5772 mL	27.8862 mL
20 mM	0.2789 mL	1.3943 mL	2.7886 mL	13.9431 mL
50 mM	0.1115 mL	0.5577 mL	1.1154 mL	5.5772 mL
100 mM	0.0558 mL	0.2789 mL	0.5577 mL	2.7886 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc