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Anti-CHGA Antibody (8W479)
😃Good
Catalog No. TMAY-00099
Anti-CHGA Antibody (8W479) is a Mouse antibody targeting CHGA. Anti-CHGA Antibody (8W479) can be used in IHC-P.
Anti-CHGA Antibody (8W479)
Anti-CHGA Antibody (8W479)
😃Good
Catalog No. TMAY-00099
Anti-CHGA Antibody (8W479) is a Mouse antibody targeting CHGA. Anti-CHGA Antibody (8W479) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CHGA Antibody (8W479) is a Mouse antibody targeting CHGA. Anti-CHGA Antibody (8W479) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8W479 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human ChromograninA in human pancreas with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ChromograninA in human adrenal gland with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the N-terminus of the Human Chromogranin A. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. The CHGA promoter haplotype 2 (occurring in a large proportion of the world population) in enhancing CHGA expression in haplotype 2 carriers who may be at higher risk for cardiovascular/metabolic disorders. Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive renal disease (nephrosclerosis). Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. The chromogranin/secretogranin proteins are costored and coreleased with catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons. Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. CHGA is a candidate gene for autonomic dysfunction syndromes, including intermediate phenotypes that contribute to human hypertension. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human Chromogranin A |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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