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Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2 (Synonyms: p-IRF3 (Ser386), p-IRF3 (S386), IRF3 (p-Ser386), ...)
Catalog No. TMAC-02218 Copy Product Info
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Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody can be used in WB.
Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody 2
Copy Product Info🥰Excellent
Catalog No. TMAC-02218
Synonyms p-IRF3 (Ser386), p-IRF3 (S386), IRF3 (p-Ser386), IRF3 (p-S386)
Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody can be used in WB.
Anti-Phospho-IRF3
(Ser386) Polyclonal Antibody 2
(Ser386) Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $316 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Polyclonal Antibody can be used in WB. |
| Synonyms | p-IRF3 (Ser386), p-IRF3 (S386), IRF3 (p-Ser386), IRF3 (p-S386) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of extracts from untreated and treated 293T cell lysate using IRF-3 (Phospho-Ser386) Antibody TMAC-02218 at 1/500 dilution.  |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of Serine 386(A-S-S(p)-L-E) derived from Human IRF-3 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 55 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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